Synthesis and Biological Assay of Small-Molecule Quorum Sensing Inhibitors: A Three-Week Course-Based Undergraduate Research Experience

被引：9
作者：
Dorn, Stanna K. [1 ]
Newman, Jane D. [2 ,3 ]
van Kessel, Julia C. [2 ]
Brown, Laura C. [1 ]
机构：
[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA
[2] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA
[3] Adrian Coll, Adrian, MI 49221 USA
来源：
JOURNAL OF CHEMICAL EDUCATION | 2021年 / 98卷 / 11期
基金：
美国国家卫生研究院;
关键词：
Second-Year Undergraduate; Upper-Division Undergraduate; Organic Chemistry; Inquiry-Based/Discovery Learning; Combinatorial Chemistry; Medicinal Chemistry; Undergraduate Research; PROJECT; INTEGRATION; EDUCATION; STUDENTS; LUXR;
D O I：
10.1021/acs.jchemed.1c00596
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We have developed a course-based undergraduate research experience (CURE) that can be carried out in the context of an existing second-semester or upper-level organic laboratory course. In this three-week laboratory module, students synthesize a small library of molecules, test them in a robust biological assay, and design a new compound library on the basis of their results.
引用
收藏
页码：3533 / 3541
页数：9
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