Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension

被引：6

作者：

Richter, Manuel J. ^{[1
,2
,3
]}

Harutyunova, Satenik ^{[4
]}

Bollmann, Tom ^{[5
]}

Classen, Simon ^{[6
]}

Fuge, Jan ^{[3
,7
]}

Gall, Henning ^{[2
,3
]}

Gerhardt, Felix ^{[8
,9
]}

Ghofrani, Hossein A. ^{[1
,2
,3
,10
]}

Gunkel, Hartmut ^{[11
]}

Gruenig, Ekkehard ^{[4
]}

Halank, Michael ^{[12
]}

Heine, Alexander ^{[5
]}

Klose, Hans ^{[13
]}

Lange, Tobias J. ^{[14
]}

Neurohr, Claus ^{[15
]}

Nickolaus, Kai ^{[1
]}

Opitz, Christian F. ^{[16
]}

Rosenkranz, Stephan ^{[8
,9
]}

Seyfarth, Hans-Juergen ^{[17
]}

Tello, Khodr ^{[2
,3
]}

Ewert, Ralf ^{[5
]}

Olsson, Karen M. ^{[3
,7
]}

机构：

[1] Kerckhoff Heart Rheuma & Thorac Ctr, Dept Pneumol, Bad Nauheim, Germany

[2] UGMLC, Justus Liebig Univ Giessen, Dept Internal Med, Klinikstr 36, D-35392 Giessen, Germany

[3] German Ctr Lung Res DZL, Klinikstr 36, D-35392 Giessen, Germany

[4] Univ Hosp Heidelberg, Thorax Clin, Ctr Pulm Hypertens, Heidelberg, Germany

[5] Ernst Moritz Arndt Univ Greifswald, Dept Internal Med, Greifswald, Germany

[6] Kerckhoff Heart Rheuma & Thorac Ctr, Dept Vasc Surg, Bad Nauheim, Germany

[7] Hannover Med Sch, Dept Resp Med, Hannover, Germany

[8] Cologne Univ, Heart Ctr, Dept Internal Med 3, Cologne, Germany

[9] Cologne Univ, Heart Ctr, CCRC, Cologne, Germany

[10] Imperial Coll London, Dept Med, London, England

[11] pro samed GmbH, Berlin, Germany

[12] Univ Hosp Carl Gustav Carus, Dept Internal Med 1, Dresden, Germany

[13] Univ Hamburg, Dept Pneumol, Hamburg, Germany

[14] Univ Med Ctr Regensburg, Div Pneumol, Dept Internal Med 2, Regensburg, Germany

[15] Robert Bosch Hosp, Dept Pneumol & Resp Med, Gerlingen, Germany

[16] DRK Kliniken Berlin, Dept Cardiol, Berlin, Germany

[17] Univ Leipzig, Dept Pneumol, Leipzig, Germany

来源：

PULMONARY CIRCULATION | 2020年 / 10卷 / 01期

关键词：

implantable infusion pump; pulmonary hypertension; treatment; prostanoid; SYSTEM; SAFETY;

D O I：

10.1177/2045894020910136

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Implantable infusion pumps might improve the convenience and safety of intravenous treprostinil for pulmonary arterial hypertension. The LENUS Pro (R) pump (approved in Europe) has a fixed flow rate. Based on 126 pumps and 2853 refills, we retrospectively analyzed the actual flow rate from 09/2010 to 09/2018. A relevant flow rate variance is evident after three years; therefore, flow rate monitoring and dose adjustment are mandatory.

引用

页数：5

共 12 条

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