Pd-Catalyzed Transfer of Difluorocarbene

被引：107
|
作者：
Deng, Xiao-Yun [1 ]
Lin, Jin-Hong [1 ]
Xiao, Ji-Chang [1 ]
机构：
[1] Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 17期
关键词：
COPPER-MEDIATED DIFLUOROMETHYLATION; C-F BONDS; DIAZO-COMPOUNDS; COMPLEXES; TRIFLUOROMETHYLATION; IODIDES; ARYL; TETRAFLUOROETHYLENE; PHOSPHABETAINE; METATHESIS;
D O I：
10.1021/acs.orglett.6b02141
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The study of transition-metal difluorocarbene complex has long been a subject of active investigation, but the transition-metal-catalyzed transfer of difluorocarbene remains a significant challenge. The Pd-catalyzed transfer of difluorocarbene is described to realize the coupling reaction of boronic acids with difluorocarbene to give (difluoromethyl)arenes and -olefins. Mechanistic investigations reveal that the Pd=CF2 complex is an important intermediate for this transformation. This complex is prone to trimerization without the presence of starting materials.
引用
收藏
页码：4384 / 4387
页数：4
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