Pd-Catalyzed Transfer of Difluorocarbene

被引：111

作者：

Deng, Xiao-Yun ^{[1
]}

Lin, Jin-Hong ^{[1
]}

Xiao, Ji-Chang ^{[1
]}

机构：

[1] Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 17期

关键词：

COPPER-MEDIATED DIFLUOROMETHYLATION; C-F BONDS; DIAZO-COMPOUNDS; COMPLEXES; TRIFLUOROMETHYLATION; IODIDES; ARYL; TETRAFLUOROETHYLENE; PHOSPHABETAINE; METATHESIS;

D O I：

10.1021/acs.orglett.6b02141

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The study of transition-metal difluorocarbene complex has long been a subject of active investigation, but the transition-metal-catalyzed transfer of difluorocarbene remains a significant challenge. The Pd-catalyzed transfer of difluorocarbene is described to realize the coupling reaction of boronic acids with difluorocarbene to give (difluoromethyl)arenes and -olefins. Mechanistic investigations reveal that the Pd=CF2 complex is an important intermediate for this transformation. This complex is prone to trimerization without the presence of starting materials.

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收藏

页码：4384 / 4387

页数：4

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