Characterization of Hydrophilic Polymers as a Syringe Extrusion 3D Printing Material for Orodispersible Film

被引:27
作者
Panraksa, Pattaraporn [1 ]
Qi, Sheng [2 ]
Udomsom, Suruk [3 ]
Tipduangta, Pratchaya [1 ]
Rachtanapun, Pornchai [4 ,5 ]
Jantanasakulwong, Kittisak [4 ,5 ]
Jantrawut, Pensak [1 ,5 ]
机构
[1] Chiang Mai Univ, Fac Pharm, Dept Pharmaceut Sci, Chiang Mai 50200, Thailand
[2] Univ East Anglia, Sch Pharm, Norwich NR4 7TJ, Norfolk, England
[3] Chiang Mai Univ, Biomed Engn Inst, Chiang Mai 50200, Thailand
[4] Chiang Mai Univ, Fac Agroind, Sch Agroind, Div Packaging Technol, Chiang Mai 50100, Thailand
[5] Chiang Mai Univ, Cluster Agro BioCircular Green Ind Agro BCG, Chiang Mai 50100, Thailand
关键词
syringe extrusion 3D printing; orodispersible film; hydrophilic polymer; disintegration; HYDROXYPROPYL METHYLCELLULOSE; DRUG-DELIVERY; FORMULATION; ROUGHNESS; TABLETS; RELEASE;
D O I
10.3390/polym13203454
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
The application of hydrophilic polymers in designing and three-dimensional (3D) printing of pharmaceutical products in various dosage forms has recently been paid much attention. Use of hydrophilic polymers and syringe extrusion 3D printing technology in the fabrication of orodispersible films (ODFs) might hold great potential in rapid drug delivery, personalized medicine, and manufacturing time savings. In this study, the feasibility of 3D-printed ODFs fabrication through a syringe extrusion 3D printing technique and using five different hydrophilic polymers (e.g., hydroxypropyl methylcellulose E15, hydroxypropyl methylcellulose E50, high methoxyl pectin, sodium carboxymethylcellulose, and hydroxyethylcellulose) as film-forming polymers and printing materials has been investigated. Rheology properties and printability of printing gels and physicochemical and mechanical properties of 3D-printed ODFs were evaluated. Amongst the investigated hydrophilic polymers, sodium carboxymethylcellulose at a concentration of 5% w/v (SCMC-5) showed promising results with a good printing resolution and accurate dimensions of the 3D-printed ODFs. In addition, SCMC-5 3D-printed ODFs exhibited the fastest disintegration time within 3 s due to high wettability, roughness and porosity on the surface. However, the results of the mechanical properties study showed that SCMC-5 3D printed ODFs were rigid and brittle, thus requiring special packaging to prevent them from any damage before practical use.
引用
收藏
页数:14
相关论文
共 46 条
[21]   3D inkjet printing of tablets exploiting bespoke complex geometries for controlled and tuneable drug release [J].
Kyobula, Mary ;
Adedeji, Aremu ;
Alexander, Morgan R. ;
Saleh, Ehab ;
Wildman, Ricky ;
Ashcroft, Ian ;
Gellert, Paul R. ;
Roberts, Clive J. .
JOURNAL OF CONTROLLED RELEASE, 2017, 261 :207-215
[22]   Orally disintegrating films focusing on formulation, manufacturing process, and characterization [J].
Lee Y. ;
Kim K. ;
Kim M. ;
Choi D.H. ;
Jeong S.H. .
Journal of Pharmaceutical Investigation, 2017, 47 (3) :183-201
[23]   3D printing for drug manufacturing: A perspective on the future of pharmaceuticals [J].
Lepowsky, Eric ;
Tasoglu, Savas .
INTERNATIONAL JOURNAL OF BIOPRINTING, 2018, 4 (01)
[24]   Direct ink writing of 3D functional materials [J].
Lewis, Jennifer A. .
ADVANCED FUNCTIONAL MATERIALS, 2006, 16 (17) :2193-2204
[25]   Preparation and investigation of novel gastro-floating tablets with 3D extrusion-based printing [J].
Li, Qijun ;
Guan, Xiaoying ;
Cui, Mengsuo ;
Zhu, Zhihong ;
Chen, Kai ;
Wen, Haoyang ;
Jia, Danyang ;
Hou, Jian ;
Xu, Wenting ;
Yang, Xinggang ;
Pan, Weisan .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2018, 535 (1-2) :325-332
[26]  
Ma Yanhang, 2018, Enzymes, V43, P11, DOI 10.1016/bs.enz.2018.07.002
[27]   The effect of the degree of hydrolysis of the PVA and the plasticizer concentration on the color, opacity, and thermal and mechanical properties of films based on PVA and gelatin blends [J].
Maria, Thais M. C. ;
de Carvalho, Rosemary A. ;
Sobral, Paulo J. A. ;
Habitante, Ana Monica B. Q. ;
Solorza-Feria, Javier .
JOURNAL OF FOOD ENGINEERING, 2008, 87 (02) :191-199
[28]   Simulated Biological Fluids with Possible Application in Dissolution Testing [J].
Marques, Margareth R. C. ;
Loebenberg, Raimar ;
Almukainzi, May .
DISSOLUTION TECHNOLOGIES, 2011, 18 (03) :15-28
[29]   Formulation Optimization of Selective Laser Sintering 3D-Printed Tablets of Clindamycin Palmitate Hydrochloride by Response Surface Methodology [J].
Mohamed, Eman M. ;
Ali, Sogra F. Barakh ;
Rahman, Ziyaur ;
Dharani, Sathish ;
Ozkan, Tanil ;
Kuttolamadom, Mathew A. ;
Khan, Mansoor A. .
AAPS PHARMSCITECH, 2020, 21 (06)
[30]  
Mohamed MI., 2011, J CHEM PHARM RES, V3, P665