Prediction of 28-days mortality with sequential organ failure assessment (SOFA), quick SOFA (qSOFA) and systemic inflammatory response syndrome (SIRS) - A retrospective study of medical patients with acute infectious disease

Aims: Evaluating the use of sequential organ failure assessment (SOFA) 2 compared to quick SOFA (qSOFA) and to systemic inflammatory response syndrome (SIRS) in assessing 28- days mortality in medical patients with acute infection. Methods: In total, 323 patients with verified infection were stratified in accordance to Sepsis- 3. SOFA, qSOFA and SIRS were calculated using registered variables. Adverse outcome was death within 28- days of admission. Results: In total, 190 (59%) patients had a SOFA score 2 and the overall in- hospital mortality was 21 (6%). Scores of SOFA and qSOFA were both significantly elevated in non- survivors. SOFA showed good accuracy (Area under the receiver operating characteristic (AUROC) = 0.83, 95% CI, 0.76 - 0.90) for 28- days mortality compared with qSOFA (AUROC = 0.67, 95% CI, 0.54 - 0.80) and SIRS (AUROC = 0.62, 95% Cl 0.49 0.74). SOFA was 2 in all patients who died, while qSOFA and SIRS was 2 in 8 (38%) and 17 (81%) of the patients who died, respectively. Conclusion: SOFA score 2 was better than SIRS and qSOFA to predict mortality within 28- days of admission among patients with acute infectious disease. (c) 2018 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.