Selective Simultaneous Determination of Paracetamol and Uric Acid Using a Glassy Carbon Electrode Modified with Multiwalled Carbon Nanotube/Chitosan Composite

被引：36
作者：
Babaei, Ali [1 ,2 ]
Garrett, David J. [2 ]
Downard, Alison J. [2 ]
机构：
[1] Univ Arak, Dept Chem, Arak 38156, Iran
[2] Univ Canterbury, Dept Chem, Christchurch 8140, New Zealand
来源：
ELECTROANALYSIS | 2011年 / 23卷 / 02期
关键词：
Paracetamol; Uric acid; Carbon nanotubes; Chitosan; Modified glassy carbon; NANOTUBES-CHITOSAN COMPOSITE; FLOW-INJECTION; DIRECT ELECTROCHEMISTRY; VOLTAMMETRIC METHOD; ACETAMINOPHEN; OXIDATION; ENZYMES; TABLETS; SYSTEM; SERUM;
D O I：
10.1002/elan.201000406
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A multiwalled carbon nanotube/chitosan modified glassy carbon electrode (MWCNTs-CHT/GCE) has been used for simultaneous determination of paracetamol (PAR) and uric acid (UA). The measurements were carried out using differential pulse voltammetry (DPV), cyclic voltammetry (CV) and chronoamperometry (CA). DPV measurements showed a linear relationship between oxidation peak current and concentration of PAR and UA in phosphate buffer (pH 7) over the concentration range 2 mu M to 250 mu M, and 10 mu M to 400 mu M, respectively. The analytical performance of this sensor has been evaluated for detection of PAR and UA in human serum and human urine with satisfactory results.
引用
收藏
页码：417 / 423
页数：7
相关论文
共 40 条
  • [1] A Glassy Carbon Electrode Modified with Multiwalled Carbon Nanotube/Chitosan Composite as a New Sensor for Simultaneous Determination of Acetaminophen and Mefenamic Acid in Pharmaceutical Preparations and Biological Samples
    Babaei, Ali
    Afrasiabi, Mohammad
    Babazadeh, Mitra
    [J]. ELECTROANALYSIS, 2010, 22 (15) : 1743 - 1749
  • [2] Carbon nanotubes - the route toward applications
    Baughman, RH
    Zakhidov, AA
    de Heer, WA
    [J]. SCIENCE, 2002, 297 (5582) : 787 - 792
  • [3] Paracetamol in the treatment of osteoarthritis pain
    Brandt, K
    [J]. DRUGS, 2003, 63 : 23 - 41
  • [4] AN IMPROVED VOLTAMMETRIC METHOD FOR THE DETERMINATION OF TRACE AMOUNTS OF URIC-ACID WITH ELECTROCHEMICALLY PRETREATED CARBON-PASTE ELECTRODES
    CAI, XH
    KALCHER, K
    NEUHOLD, C
    OGOREVC, B
    [J]. TALANTA, 1994, 41 (03) : 407 - 413
  • [5] Fast determination of paracetamol by using a very simple photometric flow-through sensing device
    Cañada, MJA
    Reguera, MIP
    Medina, AR
    de Córdova, MLF
    Díaz, AM
    [J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2000, 22 (01) : 59 - 66
  • [6] Fabrication of tyrosinase biosensor based on multiwalled carbon nanotubes-chitosan composite and its application to rapid determination of coliforms
    Cheng, Ynxiao
    Liu, Yajun
    Huang, Jingjing
    Xian, Yuezhong
    Zhang, Zhonghai
    Jin, Litong
    [J]. ELECTROANALYSIS, 2008, 20 (13) : 1463 - 1469
  • [7] The synthesis and morphology characteristic study of BAO-ODPA polyimide/TiO2 nano hybrid films
    Chiang, PC
    Whang, WT
    [J]. POLYMER, 2003, 44 (08) : 2249 - 2254
  • [8] DUTT V V S E, 1974, Analytical Chemistry, V46, P1777, DOI 10.1021/ac60348a041
  • [9] Direct determination of uric acid in serum by a fluorometric-enzymatic method based on uricase
    Galbán, J
    Andreu, Y
    Almenara, MJ
    de Marcos, S
    Castillo, JR
    [J]. TALANTA, 2001, 54 (05) : 847 - 854
  • [10] Conducting polymer nanocomposites: A brief overview
    Gangopadhyay, R
    De, A
    [J]. CHEMISTRY OF MATERIALS, 2000, 12 (03) : 608 - 622
1234