A General and Selective Iron-Catalyzed Aminocarbonylation of Alkynes: Synthesis of Acryl- and Cinnamides

被引：102
作者：
Driller, Katrin Marie [1 ]
Prateeptongkum, Saisuree [1 ]
Jackstell, Ralf [1 ]
Beller, Matthias [1 ]
机构：
[1] Leibniz Inst Katalyse eV, D-18059 Rostock, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 02期
关键词：
acrylamides; carbonylation; cinnamides; homogeneous catalysis; iron; CROSS-COUPLING REACTIONS; P-ARYLTHIO CINNAMIDES; EFFICIENT SYNTHESIS; ALPHA; BETA-UNSATURATED AMIDES; CARBONYL-COMPLEXES; (E)-ALPHA; TRANSFER HYDROGENATION; ALLYLIC SUBSTITUTION; CYCLOBUTENEDIONES; METAL;
D O I：
10.1002/anie.201005823
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Entering the iron age: The first general method for iron-catalyzed monocarbonylation of alkynes has been developed. A range of structurally diverse cinnamides and acrylamides have been obtained smoothly starting from commercially available amines and alkynes in the presence of [Fe 3(CO)12] and ligand L (see scheme). The method is highly chemo- and regioselective and requires no expensive catalyst. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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收藏
页码：537 / 541
页数：5
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