PNEUMOCOCCAL MENINGITIS IN FRENCH CHILDREN BEFORE AND AFTER THE INTRODUCTION OF PNEUMOCOCCAL CONJUGATE VACCINE

被引：35

作者：

Levy, Corinne ^{[1
,2
]}

Varon, Emmanuelle ^{[1
,3
]}

Bingen, Edouard ^{[1
,4
]}

Lecuyer, Aurelie ^{[1
,2
]}

Boucherat, Michel ^{[2
]}

Cohen, Robert ^{[1
,2
,5
]}

机构：

[1] SFP, GPIP, Paris, France

[2] ACTIV Assoc Clin & Therapeut Infantile Val Marne, Paris, France

[3] HEGP, Ctr Natl Reference Pneumocoques, Paris, France

[4] Univ Paris 07, Hop Robert Debre, AP HP, Microbiol Serv, Paris, France

[5] Ctr Hosp Intercommunal, Creteil, France

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2011年 / 30卷 / 02期

关键词：

pneumococcal meningitis; children; STREPTOCOCCUS-PNEUMONIAE; UNITED-STATES; EPIDEMIOLOGY; INFECTIONS; DISEASE; ERA;

D O I：

10.1097/INF.0b013e3181f4cf69

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In France, despite a high rate of pneumococcal conjugate vaccine coverage, the number of cases of pneumococcal meningitis in children did not decline significantly between 2001-2002 (n = 264) and 2007-2008 (n = 244). A decline was observed among children <2 years old (185 [70.1%] to 134 [54.9%] cases; P = 0.0004), but was counterbalanced by an increase among children >= 2 years old (79 [29.9%] to 110 [45.1%] cases). Mean age increased significantly, from 2.3 (median 0.8) to 3.8 (median 1.5) years. After pneumococcal conjugate vaccine 7 implementation, a wide diversity of serotypes implicated in pneumococcal meningitis was observed; serotypes 19A and 7F were the most frequent.

引用

页码：168 / 170

页数：3

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