Pyroptosis-related gene expression patterns and corresponding tumor microenvironment infiltration characterization in ovarian cancer

被引：10

作者：

Liu, Jinhui ^{[1
]}

Chen, Can ^{[2
]}

Geng, Rui ^{[3
]}

Shao, Fang ^{[3
]}

Yang, Sheng ^{[3
]}

Zhong, Zihang ^{[3
]}

Ni, Senmiao ^{[3
]}

Bai, Jianling ^{[3
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Gynecol, Nanjing 210029, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Affiliated Hosp 1, Dept Lab Med, 300 Guang Zhou Rd, Nanjing 210029, Jiangsu, Peoples R China

[3] Nanjing Med Univ, Sch Publ Heath, Dept Biostat, 101 Longmian Ave, Nanjing 211166, Peoples R China

来源：

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL | 2022年 / 20卷

基金：

中国国家自然科学基金;

关键词：

Pyroptosis; TCGA; Ovarian cancer; Tumor immune environment; Immune checkpoint inhibitors; ANTI-PD-1; ANTIBODY; ANTITUMOR-ACTIVITY; CELL-DEATH; SAFETY; IMMUNOTHERAPY; INFLAMMASOMES; INHIBITOR; DISCOVERY; CISPLATIN;

D O I：

10.1016/j.csbj.2022.09.037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pyroptosis, a form of inflammatory programmed cell death, is accompanied by inflammation and partic-ipate in the body's immune response. The expression of pyroptosis-related genes (PRGs) is associated with tumor prognosis in ovarian cancer (OC), but it is still unknown whether pyroptosis can affect tumor immune microenvironment (TME) of OC. Based on 30 PRGs, we comprehensively assessed the pyroptosis patterns by using PRGscore and correlated them with TME features in 474 OC patients. Finally, we iden-tified three pyroptosis modification patterns and TME immune characteristics of these patterns were in response to three immune phenotypes (immune-desert, immune-inflamed, and immune-excluded phe-notypes). PRGscore can predict patient survival, staging, grading, and immunotherapy efficacy. Low PRGscore was associated with better survival advantage and increased mutation burden. Low PRGscore patients showed significantly better therapeutic effects and clinical results in chemotherapy and immunotherapy. Besides, the capability of PRGscore in predicting prognosis and immunotherapy sensitivity was further verified in other three tumor cohorts. In conclusion, the comprehensive assess-ment of OC pyroptosis modifications can help enhancing our understanding of TME immune infiltration and provide better personalized treatment tactics for OC patients.(c) 2022 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY-NC-ND license (http://creative-commons.org/licenses/by-nc-nd/4.0/).

引用

页码：5440 / 5452

页数：13

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