Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

被引：2905

作者：

Atarashi, Koji ^{[1
]}

Tanoue, Takeshi ^{[1
]}

Shima, Tatsuichiro ^{[2
]}

Imaoka, Akemi ^{[2
]}

Kuwahara, Tomomi ^{[3
]}

Momose, Yoshika ^{[4
]}

Cheng, Genhong ^{[5
]}

Yamasaki, Sho ^{[6
]}

Saito, Takashi ^{[6
]}

Ohba, Yusuke ^{[7
]}

Taniguchi, Tadatsugu ^{[1
]}

Takeda, Kiyoshi ^{[8
]}

Hori, Shohei ^{[9
]}

Ivanov, Ivaylo I. ^{[10
]}

Umesaki, Yoshinori ^{[2
]}

Itoh, Kikuji ^{[4
]}

Honda, Kenya ^{[1
,11
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Immunol, Tokyo 1130033, Japan

[2] Yakult Cent Inst Microbiol Res, Tokyo 1868650, Japan

[3] Univ Tokushima, Grad Sch, Inst Hlth Biosci, Dept Mol Bacteriol, Tokushima 7708503, Japan

[4] Univ Tokyo, Dept Vet Publ Hlth, Tokyo 1138657, Japan

[5] Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

[6] RIKEN Res Ctr Allergy & Immunol, Lab Cell Signaling, Kanagawa 2300045, Japan

[7] Hokkaido Univ, Grad Sch Med, Lab Pathophysiol & Signal Transduct, Sapporo, Hokkaido 0608638, Japan

[8] Osaka Univ, Grad Sch Med, Lab Immune Regulat, Suita, Osaka 5650871, Japan

[9] RIKEN Res Ctr Allergy & Immunol, Res Unit Immune Homeostasis, Kanagawa 2300045, Japan

[10] Columbia Univ, Med Ctr, Dept Microbiol & Immunol, New York, NY 10032 USA

[11] Japan Sci & Technol Agcy, Precursory Res Embryon Sci & Technol PRESTO, Kawaguchi, Saitama 3320012, Japan

来源：

SCIENCE | 2011年 / 331卷 / 6015期

关键词：

SEGMENTED FILAMENTOUS BACTERIA; INTESTINAL IMMUNE-RESPONSES; MICROBIOTA; INTERLEUKIN-10; HOMEOSTASIS; COLITIS; INFLAMMATION; SYSTEM; BETA;

D O I：

10.1126/science.1198469

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

CD4(+) T regulatory cells (T-regs), which express the Foxp3 transcription factor, play a critical role in the maintenance of immune homeostasis. Here, we show that in mice, T-regs were most abundant in the colonic mucosa. The spore-forming component of indigenous intestinal microbiota, particularly clusters IV and XIVa of the genus Clostridium, promoted T-reg cell accumulation. Colonization of mice by a defined mix of Clostridium strains provided an environment rich in transforming growth factor-beta and affected Foxp3(+) T-reg number and function in the colon. Oral inoculation of Clostridium during the early life of conventionally reared mice resulted in resistance to colitis and systemic immunoglobulin E responses in adult mice, suggesting a new therapeutic approach to autoimmunity and allergy.

引用

页码：337 / 341

页数：5