The Therapeutic Value and Molecular Mechanisms of lncRNA FENDRR in Human Cancer

被引：7
作者：
Xu, Wen [1 ]
Wang, Bei [1 ]
Cai, Yuxuan [1 ]
Chen, Jinlan [1 ]
Meng, Enqing [1 ]
Guo, Chong [1 ]
Zhou, Gang [2 ,3 ]
Yuan, Chengfu [1 ,4 ]
机构：
[1] China Three Gorges Univ, Coll Med Sci, Yichang 443002, Peoples R China
[2] China Three Gorges Univ, Coll Tradit Chinese Med, Yichang 443002, Peoples R China
[3] Yichang Hosp Tradit Chinese Med, Yichang 443002, Peoples R China
[4] China Three Gorges Univ, Grade Pharmacol Lab Chinese Med 3, State Adm Tradit Chinese Med, Yichang 443002, Peoples R China
来源：
CURRENT PHARMACEUTICAL DESIGN | 2021年 / 27卷 / 39期
基金：
中国国家自然科学基金;
关键词：
Long non-coding RNA; FENDRR; cancer; biomarkers; therapeutic targets; clinical prognosis; LONG NONCODING RNA; PROLIFERATION; EXPRESSION; CELLS;
D O I：
10.2174/1381612827666210820094702
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background: Long noncoding RNA (lncRNA) fetal-lethal non-coding developmental regulatory RNA (FENDRR), a newly known lncRNA, has been reported to be abnormally expressed in diverse tumors. This review is focused on clarifying the mechanism of FENDRR to regulate the biological process of tumors, affirming its value as a target for tumor therapy. Methods: The pathophysiological mechanism of FENDRR acting on tumors has been analyzed and summarized by reviewing PubMed. Results: The expression of lncRNA FENDRR is abnormally altered in clinical cancers, promoting the malignant transformation of a variety of tumors, including colon cancer, cervical cancer, hepatocellular carcinoma, prostate cancer, Malignant melanoma, lung cancer, osteosarcoma, breast cancer, etc. Cellular processions, including proliferation, invasion, apoptosis and migration affected by FENDRR, have been revealed. Conclusion: Specific evidences for the involvement of LncRNA FENDRR in cancer regulatory processes suggest that FENDRR has the potential to be a biomarker or clinical therapeutic target for malignant tumors.
引用
收藏
页码：4100 / 4106
页数：7
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