Recent Advances in chemistry and pharmacology of 2-methoxyestradiol: An anticancer investigational drug

被引：52

作者：

Kumar, B. Sathish ^{[1
]}

Raghuvanshi, Dushyant Singh ^{[1
]}

Hasanain, Mohammad ^{[2
]}

Alam, Sarfaraz ^{[1
]}

Sarkar, Jayanta ^{[2
]}

Mitra, Kalyan ^{[2
]}

Khan, Feroz ^{[1
]}

Negi, Arvind S. ^{[1
]}

机构：

[1] Cent Inst Med & Aromat Plants, CSIR, Kukrail Picn Spot Rd,PO CIMAP, Lucknow 226015, Uttar Pradesh, India

[2] Cent Drug Res Inst, CSIR, BS 10-1,Sect 10,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India

来源：

STEROIDS | 2016年 / 110卷

关键词：

2-Methoxyestradiol; Anticancer; Structure-activity relationship; Synthetic derivatives; Clinical trials; ENDOGENOUS ESTROGEN METABOLITE; CELL-CYCLE PROGRESSION; COLCHICINE-BINDING-SITE; PROSTATE-CANCER CELLS; SMOOTH-MUSCLE-CELLS; BREAST-CANCER; IN-VITRO; TUBULIN POLYMERIZATION; LIQUID-CHROMATOGRAPHY; ANTIMITOTIC ACTIVITY;

D O I：

10.1016/j.steroids.2016.03.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2-Methoxyestradiol (2ME(2)), an estrogen hormone metabolite is a potential cancer chemotherapeutic agent. Presently, it is an investigational drug under various phases of clinical trials alone or in combination therapy. Its anticancer activity has been attributed to its antitubulin, antiangiogenic, pro-apoptotic and ROS induction properties. This anticancer drug candidate has been explored extensively in last twenty years for its detailed chemistry and pharmacology. Present review is an update of its chemistry and biological activity. It also extends an assessment of potential of 2ME(2) and its analogues as possible anticancer drug in future. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：9 / 34

页数：26

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