House dust mite-derived serine protease upregulates gene expression of interleukin-33 in canine keratinocytes via protease-activated receptor-2
被引:3
|
作者:
Nishimura, Rinka
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Fac Agr, Cooperat Dept Vet Med, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, JapanTokyo Univ Agr & Technol, Fac Agr, Cooperat Dept Vet Med, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, Japan
Nishimura, Rinka
[1
]
Miyajima, Masaki
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Fac Agr, Cooperat Dept Vet Med, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, JapanTokyo Univ Agr & Technol, Fac Agr, Cooperat Dept Vet Med, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, Japan
Miyajima, Masaki
[1
]
Takahashi, Kaho
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Fac Agr, Cooperat Dept Vet Med, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, JapanTokyo Univ Agr & Technol, Fac Agr, Cooperat Dept Vet Med, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, Japan
Takahashi, Kaho
[1
]
Hirokawa, Marin
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Fac Agr, Cooperat Dept Vet Med, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, JapanTokyo Univ Agr & Technol, Fac Agr, Cooperat Dept Vet Med, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, Japan
Hirokawa, Marin
[1
]
Hara, Yuna
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Univ Agr & Technol, Fac Agr, Cooperat Dept Vet Med, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, JapanTokyo Univ Agr & Technol, Fac Agr, Cooperat Dept Vet Med, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, Japan
Hara, Yuna
[1
]
Kimura, Junpei
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Vet Med, 1 Gwanak Ro, Seoul 08826, South Korea
Seoul Natl Univ, Res Inst Vet Med, 1 Gwanak Ro, Seoul 08826, South KoreaTokyo Univ Agr & Technol, Fac Agr, Cooperat Dept Vet Med, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, Japan
Kimura, Junpei
[2
,3
]
论文数: 引用数:
h-index:
机构:
Ohmori, Keitaro
[1
]
机构:
[1] Tokyo Univ Agr & Technol, Fac Agr, Cooperat Dept Vet Med, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, Japan
[2] Seoul Natl Univ, Coll Vet Med, 1 Gwanak Ro, Seoul 08826, South Korea
[3] Seoul Natl Univ, Res Inst Vet Med, 1 Gwanak Ro, Seoul 08826, South Korea
Background The involvement of interleukin (IL)-33 produced by keratinocytes has been suggested in the pathogenesis of canine atopic dermatitis (cAD). House dust mite (HDM)-derived proteases induce the production of various cytokines and chemokines in keratinocytes via protease-activated receptor-2 (PAR-2); however, their effects on IL-33 mRNA expression in canine keratinocytes have not been determined. Hypothesis/Objective To clarify whether HDM-derived proteases induce IL-33 mRNA expression in canine keratinocytes via PAR-2. Methods and materials Expression of IL-33 mRNA was quantified by real-time PCR in a cell line of canine progenitor epidermal keratinocytes (CPEK) stimulated with Dermatophagoides farinae (Der f) whole body extract, Der f pre-treated with cysteine protease and serine protease inhibitors, and trypsin. Trypsin and Der f-mediated IL-33 mRNA expression also was measured in CPEK cells treated with a PAR-2 antagonist. Results Der f enhanced IL-33 mRNA expression in CPEK cells in incubation time- and dose-dependent manners. Der f pre-treated with a serine protease inhibitor, and not a cysteine protease inhibitor, abrogated an increase in IL-33 mRNA expression in CPEK cells. Trypsin also enhanced IL-33 mRNA expression in CPEK cells. Trypsin-mediated IL-33 mRNA expression was completely abolished by a PAR-2 antagonist, while Der f-mediated IL-33 mRNA expression was partially and significantly diminished by it. Conclusions and clinical relevance Der f-derived serine protease upregulated IL-33 mRNA expression in CPEK cells at least in part via PAR-2. These findings suggest that HDM may be involved in the development of (C)AD by increasing IL-33 mRNA expression in keratinocytes.
机构:
Johnson & Johnson Consumer Co Inc, CPPW, Johnson & Johnson Skin Res Ctr, Skillman, NJ USAJohnson & Johnson Consumer Co Inc, CPPW, Johnson & Johnson Skin Res Ctr, Skillman, NJ USA
Babiarz-Magee, Laura
Lin, Connie B.
论文数: 0引用数: 0
h-index: 0
机构:
Johnson & Johnson Consumer Co Inc, CPPW, Johnson & Johnson Skin Res Ctr, Skillman, NJ USAJohnson & Johnson Consumer Co Inc, CPPW, Johnson & Johnson Skin Res Ctr, Skillman, NJ USA
Lin, Connie B.
Seiberg, Miri
论文数: 0引用数: 0
h-index: 0
机构:
Johnson & Johnson Consumer Co Inc, CPPW, Johnson & Johnson Skin Res Ctr, Skillman, NJ USAJohnson & Johnson Consumer Co Inc, CPPW, Johnson & Johnson Skin Res Ctr, Skillman, NJ USA
Seiberg, Miri
Chen, Nannan
论文数: 0引用数: 0
h-index: 0
机构:
Johnson & Johnson Consumer Co Inc, CPPW, Johnson & Johnson Skin Res Ctr, Skillman, NJ USAJohnson & Johnson Consumer Co Inc, CPPW, Johnson & Johnson Skin Res Ctr, Skillman, NJ USA
机构:
Univ Nova Lisboa, NOVA Med Sch NMS, CEDOC Chron Dis Res Ctr, Fac Ciencias Med, Campo Martires,Patria 130, P-1169056 Lisbon, PortugalUniv Nova Lisboa, NOVA Med Sch NMS, CEDOC Chron Dis Res Ctr, Fac Ciencias Med, Campo Martires,Patria 130, P-1169056 Lisbon, Portugal
Moreiras, Hugo
Bento-Lopes, Liliana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nova Lisboa, NOVA Med Sch NMS, CEDOC Chron Dis Res Ctr, Fac Ciencias Med, Campo Martires,Patria 130, P-1169056 Lisbon, PortugalUniv Nova Lisboa, NOVA Med Sch NMS, CEDOC Chron Dis Res Ctr, Fac Ciencias Med, Campo Martires,Patria 130, P-1169056 Lisbon, Portugal
Bento-Lopes, Liliana
Neto, Matilde V.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nova Lisboa, NOVA Med Sch NMS, CEDOC Chron Dis Res Ctr, Fac Ciencias Med, Campo Martires,Patria 130, P-1169056 Lisbon, PortugalUniv Nova Lisboa, NOVA Med Sch NMS, CEDOC Chron Dis Res Ctr, Fac Ciencias Med, Campo Martires,Patria 130, P-1169056 Lisbon, Portugal
Neto, Matilde V.
Escrevente, Cristina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nova Lisboa, NOVA Med Sch NMS, CEDOC Chron Dis Res Ctr, Fac Ciencias Med, Campo Martires,Patria 130, P-1169056 Lisbon, PortugalUniv Nova Lisboa, NOVA Med Sch NMS, CEDOC Chron Dis Res Ctr, Fac Ciencias Med, Campo Martires,Patria 130, P-1169056 Lisbon, Portugal
Escrevente, Cristina
Cabaco, Luis C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nova Lisboa, NOVA Med Sch NMS, CEDOC Chron Dis Res Ctr, Fac Ciencias Med, Campo Martires,Patria 130, P-1169056 Lisbon, PortugalUniv Nova Lisboa, NOVA Med Sch NMS, CEDOC Chron Dis Res Ctr, Fac Ciencias Med, Campo Martires,Patria 130, P-1169056 Lisbon, Portugal
Cabaco, Luis C.
Hall, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nova Lisboa, NOVA Med Sch NMS, CEDOC Chron Dis Res Ctr, Fac Ciencias Med, Campo Martires,Patria 130, P-1169056 Lisbon, PortugalUniv Nova Lisboa, NOVA Med Sch NMS, CEDOC Chron Dis Res Ctr, Fac Ciencias Med, Campo Martires,Patria 130, P-1169056 Lisbon, Portugal
Hall, Michael J.
Ramalho, Jose S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nova Lisboa, NOVA Med Sch NMS, CEDOC Chron Dis Res Ctr, Fac Ciencias Med, Campo Martires,Patria 130, P-1169056 Lisbon, PortugalUniv Nova Lisboa, NOVA Med Sch NMS, CEDOC Chron Dis Res Ctr, Fac Ciencias Med, Campo Martires,Patria 130, P-1169056 Lisbon, Portugal
Ramalho, Jose S.
Seabra, Miguel C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nova Lisboa, NOVA Med Sch NMS, CEDOC Chron Dis Res Ctr, Fac Ciencias Med, Campo Martires,Patria 130, P-1169056 Lisbon, PortugalUniv Nova Lisboa, NOVA Med Sch NMS, CEDOC Chron Dis Res Ctr, Fac Ciencias Med, Campo Martires,Patria 130, P-1169056 Lisbon, Portugal
Seabra, Miguel C.
Barral, Duarte C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nova Lisboa, NOVA Med Sch NMS, CEDOC Chron Dis Res Ctr, Fac Ciencias Med, Campo Martires,Patria 130, P-1169056 Lisbon, PortugalUniv Nova Lisboa, NOVA Med Sch NMS, CEDOC Chron Dis Res Ctr, Fac Ciencias Med, Campo Martires,Patria 130, P-1169056 Lisbon, Portugal
机构:
Army Med Univ, Daping Hosp, Dept Neurosurg, Chongqing, Peoples R China
Army Med Univ, Inst Res Surg, Chongqing, Peoples R ChinaArmy Med Univ, Daping Hosp, Dept Neurosurg, Chongqing, Peoples R China
Li, Tian-Zun
Liu, Qiang
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, 1 Youyi Rd, Chongqing 400016, Peoples R ChinaArmy Med Univ, Daping Hosp, Dept Neurosurg, Chongqing, Peoples R China
Liu, Qiang
Xia, Yong-Zhi
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, 1 Youyi Rd, Chongqing 400016, Peoples R ChinaArmy Med Univ, Daping Hosp, Dept Neurosurg, Chongqing, Peoples R China
Xia, Yong-Zhi
论文数: 引用数:
h-index:
机构:
Darwazeh, Rami
Yan, Yi
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, 1 Youyi Rd, Chongqing 400016, Peoples R ChinaArmy Med Univ, Daping Hosp, Dept Neurosurg, Chongqing, Peoples R China
机构:
Hallym Univ, Dept Otorhinolaryngol, Kang Dong Sacred Heart Hosp, Coll Med, Seoul, South KoreaYonsei Univ, Dept Otorhinolaryngol, Coll Med, Seoul 120752, South Korea
Cho, Hyung-Ju
Lee, Hyun Jae
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Dept Otorhinolaryngol, Coll Med, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Res Ctr Human Nat Def Syst, Seoul 120752, South Korea
Yonsei Univ, Brain Korea Project Med Sci 21, Coll Med, Seoul 120752, South KoreaYonsei Univ, Dept Otorhinolaryngol, Coll Med, Seoul 120752, South Korea
Lee, Hyun Jae
Kim, Sang Cheol
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Dept Otorhinolaryngol, Coll Med, Seoul 120752, South KoreaYonsei Univ, Dept Otorhinolaryngol, Coll Med, Seoul 120752, South Korea
Kim, Sang Cheol
Kim, Kyubo
论文数: 0引用数: 0
h-index: 0
机构:
Hallym Univ, Dept Otorhinolaryngol, Kang Dong Sacred Heart Hosp, Coll Med, Seoul, South KoreaYonsei Univ, Dept Otorhinolaryngol, Coll Med, Seoul 120752, South Korea
Kim, Kyubo
Kim, Yoo Suk
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Dept Otorhinolaryngol, Coll Med, Seoul 120752, South KoreaYonsei Univ, Dept Otorhinolaryngol, Coll Med, Seoul 120752, South Korea
Kim, Yoo Suk
Kim, Chang-Hoon
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Dept Otorhinolaryngol, Coll Med, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Res Ctr Human Nat Def Syst, Seoul 120752, South Korea
Yonsei Univ, Airway Mucus Inst, Coll Med, Seoul 120752, South KoreaYonsei Univ, Dept Otorhinolaryngol, Coll Med, Seoul 120752, South Korea
Kim, Chang-Hoon
Lee, Jeung-Gweon
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Dept Otorhinolaryngol, Coll Med, Seoul 120752, South KoreaYonsei Univ, Dept Otorhinolaryngol, Coll Med, Seoul 120752, South Korea
Lee, Jeung-Gweon
Yoon, Joo-Heon
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Dept Otorhinolaryngol, Coll Med, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Res Ctr Human Nat Def Syst, Seoul 120752, South Korea
Yonsei Univ, Airway Mucus Inst, Coll Med, Seoul 120752, South Korea
Yonsei Univ, Brain Korea Project Med Sci 21, Coll Med, Seoul 120752, South KoreaYonsei Univ, Dept Otorhinolaryngol, Coll Med, Seoul 120752, South Korea
Yoon, Joo-Heon
Choi, Jae Young
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Dept Otorhinolaryngol, Coll Med, Seoul 120752, South Korea
Yonsei Univ, Brain Korea Project Med Sci 21, Coll Med, Seoul 120752, South KoreaYonsei Univ, Dept Otorhinolaryngol, Coll Med, Seoul 120752, South Korea
机构:
Yonsei Univ, Coll Med, Dept Dermatol, Seoul, South Korea
Yonsei Univ, Coll Med, Human Barrier Res Inst, Seoul, South KoreaYonsei Univ, Coll Med, Dept Dermatol, Seoul, South Korea
Lee, Si-Hyung
Kim, Ji Min
论文数: 0引用数: 0
h-index: 0
机构:
Daewoong Life Sci Res Inst, Bio R&D Ctr, Yongin, South KoreaYonsei Univ, Coll Med, Dept Dermatol, Seoul, South Korea
Kim, Ji Min
Lee, Sang Eun
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Dept Dermatol, Seoul, South Korea
Yonsei Univ, Coll Med, Human Barrier Res Inst, Seoul, South KoreaYonsei Univ, Coll Med, Dept Dermatol, Seoul, South Korea
Lee, Sang Eun
Jeong, Se Kyoo
论文数: 0引用数: 0
h-index: 0
机构:
Seowon Univ, Dept Cosmet Sci, Cheongju, South KoreaYonsei Univ, Coll Med, Dept Dermatol, Seoul, South Korea