Advances in Imaging Specific Mediators of Inflammatory Bowel Disease

被引：28
作者：
Dmochowska, Nicole
Wardill, Hannah R.
Hughes, Patrick A. [1 ]
机构：
[1] Univ Adelaide, Adelaide Med Sch, Ctr Nutr & GI Dis, Adelaide, SA 5000, Australia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 09期
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
Inflammatory Bowel Disease (IBD); colitis; PET; SPECT; microbiota; cytokine; chemokine; inflammation; CROHNS-DISEASE; GUT MICROBIOTA; IN-VIVO; EXPERIMENTAL COLITIS; FOLLOW-UP; BACTERIA; IBD; MAINTENANCE; MANAGEMENT; MECHANISMS;
D O I：
10.3390/ijms19092471
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inflammatory bowel disease (IBD) is characterized by chronic remitting and relapsing inflammation of the lower gastrointestinal tract. The etiology underlying IBD remains unknown, but it is thought to involve a hypersensitive immune response to environmental antigens, including the microbiota. Diagnosis and monitoring of IBD is heavily reliant on endoscopy, which is invasive and does not provide information regarding specific mediators. This review describes recent developments in imaging of IBD with a focus on positron emission tomography (PET) and single-photon emission computed tomography (SPECT) of inflammatory mediators, and how these developments may be applied to the microbiota.
引用
收藏
页数：13
相关论文
共 66 条
[1]   99mTc-CXCL8 SPECT to Monitor Disease Activity in Inflammatory Bowel Disease [J].
Aarntzen, Erik H. J. G. ;
Hermsen, Rick ;
Drenth, Joost P. H. ;
Boerman, Otto C. ;
Oyen, Wim J. G. .
JOURNAL OF NUCLEAR MEDICINE, 2016, 57 (03) :398-403
[2]   MECHANISMS OF DISEASE Inflammatory Bowel Disease [J].
Abraham, Clara ;
Cho, Judy H. .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (21) :2066-2078
[3]   T-cell recruitment to the intestinal mucosa [J].
Agace, William W. .
TRENDS IN IMMUNOLOGY, 2008, 29 (11) :514-522
[4]  
Alam I.S., 2018, J CLIN INVESTIG
[5]  
Allocca M., 2018, J CROHNS COLITIS
[6]   Value of colonoscopy for prediction of prognosis in patients with ulcerative colitis [J].
Ando, Takafumi ;
Nishio, Yuji ;
Watanabe, Osamu ;
Takahashi, Hironao ;
Maeda, Osamu ;
Ishiguro, Kazuhiro ;
Ishikawa, Daisuke ;
Ohmiya, Naoki ;
Niwa, Yasumasa ;
Goto, Hidemi .
WORLD JOURNAL OF GASTROENTEROLOGY, 2008, 14 (14) :2133-2138
[7]   Contribution of Clostridium difficile infection to the development of lower gastrointestinal adverse events during autologous stem cell transplantation [J].
Apewokin, S. ;
Goodwin, J. A. ;
Lee, J. Y. ;
Erickson, S. W. ;
Sanathkumar, N. ;
Raj, V. R. ;
Zhou, D. ;
McKelvey, K. D. ;
Stephens, O. ;
Coleman, E. A. .
TRANSPLANT INFECTIOUS DISEASE, 2015, 17 (04) :566-573
[8]   Gastroenterology 2 - Inflammatory bowel disease: clinical aspects and established and evolving therapies [J].
Baumgart, Daniel C. ;
Sandborn, William J. .
LANCET, 2007, 369 (9573) :1641-1657
[9]   Tc-99m HMPAO white blood cell scintigraphy in the assessment of the extent and severity of an acute exacerbation of ulcerative colitis [J].
Bennink, R ;
Peeters, M ;
D'Haens, G ;
Rutgeerts, P ;
Mortelmans, L .
CLINICAL NUCLEAR MEDICINE, 2001, 26 (02) :99-104
[10]  
Brix G, 2005, J NUCL MED, V46, P608
1234567