High Level of Genetic Compatibility between Swine-Origin H1N1 and Highly Pathogenic Avian H5N1 Influenza Viruses

被引：88
作者：
Octaviani, Cassio Pontes [1 ]
Ozawa, Makoto [2 ,4 ]
Yamada, Shinya [1 ]
Goto, Hideo [1 ]
Kawaoka, Yoshihiro [1 ,2 ,3 ,4 ,5 ,6 ]
机构：
[1] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Virol,Minato Ku, Tokyo 1088639, Japan
[2] Univ Tokyo, Inst Med Sci, Dept Special Pathogens, Int Res Ctr Infect Dis,Minato Ku, Tokyo 1088639, Japan
[3] Japan Sci & Technol Agcy, ERATO Infect Induced Host Responses Project, Kawaguchi, Saitama 3320012, Japan
[4] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Influenza Res Inst, Madison, WI 53711 USA
[5] Kobe Univ, Dept Microbiol & Infect Dis, Kobe, Hyogo 6500017, Japan
[6] Hokkaido Univ, Creat Res Initiat, Sapporo, Hokkaido 0600818, Japan
来源：
JOURNAL OF VIROLOGY | 2010年 / 84卷 / 20期
基金：
日本科学技术振兴机构;
关键词：
M2; PROTEIN; TRANSMISSION; REASSORTMENT;
D O I：
10.1128/JVI.01140-10
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Reassortment is an important mechanism for the evolution of influenza viruses. Here, we coinfected cultured cells with the pandemic swine-origin influenza virus (S-OIV) and a contemporary H5N1 virus and found that these two viruses have high genetic compatibility. Studies of human lung cell lines indicated that some reassortants had better growth kinetics than their parental viruses. We conclude that reassortment between these two viruses can occur and could create pandemic H5N1 viruses.
引用
收藏
页码：10918 / 10922
页数：5
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