Regulation of interleukin-12 production by G-protein-coupled receptors

被引：61

作者：

Braun, MC ^{[1
]}

Kelsall, BL ^{[1
]}

机构：

[1] NIAID, Immune Cell Interact Unit, Mucosal Immun Sect, Clin Invest Lab,NIH, Bethesda, MD 20892 USA

来源：

MICROBES AND INFECTION | 2001年 / 3卷 / 02期

关键词：

G protein; interleukin-12; tumor necrosis factor alpha; antigen-presenting cells; dendritic cells; monocytes; cholera toxin; pertussis toxin;

D O I：

10.1016/S1286-4579(00)01357-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

G-protein-coupled receptors have long been known to play a critical role in the recruitment and migration of leukocytes to areas of inflammation. This review will focus, however, on emerging data that G-protein-coupled receptors can modulate cytokine production by antigen-presenting cells including interleukin-12 and tumor necrosis factor-alpha and may therefore play a significant role in the regulation of innate and acquired immunity. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

页码：99 / 107

页数：9

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