Diffusion-weighted Imaging tractography-based parcellation of the human lateral premotor cortex identifies dorsal and ventral subregions with anatomical and functional specializations

被引:243
作者
Tomassini, Valentina
Jbabdi, Saad
Klein, Johannes C.
Behrens, Timothy E. J.
Pozzilli, Carlo
Matthews, Paul M.
Rushworth, Matthew F. S.
Johansen-Berg, Heidi
机构
[1] Univ Oxford, Ctr Funct MRI Brain, Oxford OX3 9DU, England
[2] Univ Oxford, Dept Expt Psychol, Oxford OX3 9DU, England
[3] Univ Roma La Sapienza, Dept Neurol Sci, I-00185 Rome, Italy
[4] GlaxoSmithKline, Hammersmith Hosp, GSK Clin Imaging Ctr, London W12 0NN, England
[5] Univ London Imperial Coll Sci Technol & Med, Dept Clin Neurosci, London W6 8RP, England
基金
英国医学研究理事会; 英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词
premotor cortex; diffusion imaging; tractography; human; prefrontal cortex; parietal cortex;
D O I
10.1523/JNEUROSCI.2144-07.2007
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Lateral premotor cortex (PM) in the macaque monkey can be segregated into structurally and functionally distinct subregions, including a major division between dorsal (PMd) and ventral (PMv) parts, which have distinct cytoarchitecture, function, and patterns of connectivity with both frontal and parietal cortical areas. The borders of their subregions are less well defined in the human brain. Here we use diffusion tractography to identify a reproducible border between dorsal and ventral subregions of human precentral gyrus. We derive connectivity fingerprints for the two subregions and demonstrate that each has a distinctive pattern of connectivity with frontal cortex and lateral parietal cortex, suggesting that these areas correspond to human PMd and PMv. Although putative human PMd has a high probability of connection with the superior parietal lobule, dorsal prefrontal cortex, and cingulate cortex, human PMv has a higher probability of connection with the anterior inferior parietal lobule and ventral prefrontal cortex. Finally, we assess the correspondence between our PMd/PMv border and local sulcal and functional anatomy. The location of the border falls at the level of the gyral branch that divides the inferior precentral sulcus from the superior precentral sulcus and corresponded closely to the location of a functional border defined using previous functional magnetic resonance imaging studies.
引用
收藏
页码:10259 / 10269
页数:11
相关论文
共 101 条
  • [31] Evidence for the involvement of the posterior parietal cortex in coordination of fingertip forces for grasp stability in manipulation
    Ehrsson, HH
    Fagergren, A
    Johansson, RS
    Forssberg, H
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 2003, 90 (05) : 2978 - 2986
  • [32] Testing anatomically specified hypotheses in functional imaging using cytoarchitectonic maps
    Eickhoff, Simon B.
    Heim, Stefan
    Zilles, Karl
    Amunts, Katrin
    [J]. NEUROIMAGE, 2006, 32 (02) : 570 - 582
  • [33] Ipsilateral cortical connections of motor, premotor, frontal eye, and posterior parietal fields in a prosimian primate, Otolemur garnetti
    Fang, PC
    Stepniewska, I
    Kaas, JH
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 2005, 490 (03) : 305 - 333
  • [34] Cortical mechanism for the visual guidance of hand grasping movements in the monkey - A reversible inactivation study
    Fogassi, L
    Gallese, V
    Buccino, G
    Craighero, L
    Fadiga, L
    Rizzolatti, G
    [J]. BRAIN, 2001, 124 : 571 - 586
  • [35] The brain differentiates human and non-human grammars: Functional localization and structural connectivity
    Friederici, AD
    Bahlmann, J
    Heim, S
    Schubotz, RI
    Anwander, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (07) : 2458 - 2463
  • [36] DEFICIT OF HAND PRESHAPING AFTER MUSCIMOL INJECTION IN MONKEY PARIETAL CORTEX
    GALLESE, V
    MURATA, A
    KASEDA, M
    NIKI, N
    SAKATA, H
    [J]. NEUROREPORT, 1994, 5 (12) : 1525 - 1529
  • [37] Precentral sulcal complex of the human brain: Morphology and statistical probability maps
    Germann, J
    Robbins, S
    Halsband, U
    Petrides, M
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 2005, 493 (03) : 334 - 356
  • [38] Functional neuroanatomy of the primate isocortical motor system
    Geyer, S
    Matelli, M
    Luppino, G
    Zilles, K
    [J]. ANATOMY AND EMBRYOLOGY, 2000, 202 (06): : 443 - 474
  • [39] Geyer S, 1998, J COMP NEUROL, V397, P231, DOI 10.1002/(SICI)1096-9861(19980727)397:2<231::AID-CNE6>3.0.CO
  • [40] 2-1