CD4+ AND CD4- CD1D-RESTRICTED NATURAL KILLER T CELLS IN PERINATALLY HIV-1 INFECTED CHILDREN RECEIVING HIGHLY ACTIVE ANTIRETROVIRAL THERAPY

被引：7
作者：
Chiappini, E. [1 ]
Betti, L. [1 ]
Bonsignori, F. [1 ]
Azzari, C. [1 ]
Galli, L. [1 ]
De Martino, M. [1 ]
机构：
[1] Univ Florence, Dept Sci Women & Childrens Hlth, Anna Meyer Childrens Univ Hosp, I-50132 Florence, Italy
来源：
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2010年 / 23卷 / 02期
关键词：
HIV-1; infection; children; NKT cells; IMMUNODEFICIENCY-VIRUS-INFECTION; NKT CELLS; HIV-1; INFECTION; ACTIVATION; EXPANSION;
D O I：
10.1177/039463201002300232
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We conducted a cross-sectional study on 43 Italian perinatally human immunodeficiency virus-type 1 (HIV-1) infected children receiving highly active antiretroviral therapy (HAART) and 26 age-matched healthy controls to explore CD1d-restricted NKT subsets. CD4(+) CD1d-rectricted natural killer (NKT) cell depletion was evidenced in 26 HIV-1 infected children with active viral replication despite HAART. Conversely, no alteration was evidenced in 17 children with undetectable viral load, suggesting full recovery in both CDC and CD4(-) CD1d-rectricted NKT cell subsets. The loss of CD4(+) NKT cells in unresponsive children may have clinical consequences, including autoimmune disorders or cancer development. Future therapeutic perspectives are suggested.
引用
收藏
页码：665 / 669
页数：5
相关论文
共 14 条
  • [1] Activation of NKT cells protects mice from tuberculosis
    Chackerian, A
    Alt, J
    Perera, V
    Behar, SM
    [J]. INFECTION AND IMMUNITY, 2002, 70 (11) : 6302 - 6309
  • [2] CD1d-restricted natural killer T cells are potent targets for human immunodeficiency virus infection
    Fleuridor, R
    Wilson, B
    Hou, R
    Landay, A
    Kessler, H
    Al-Harthi, L
    [J]. IMMUNOLOGY, 2003, 108 (01) : 3 - 9
  • [3] α-Galactosylceramide-activated Vα14 natural killer T cells mediate protection against murine malaria
    Gonzalez-Aseguinolaza, G
    de Oliveira, C
    Tomaska, M
    Hong, S
    Bruna-Romero, O
    Nakayama, T
    Taniguchi, M
    Bendelac, A
    Van Kaer, L
    Koezuka, Y
    Tsuji, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (15) : 8461 - 8466
  • [4] Distinct cytokine profiles of neonatal natural killer T cells after expansion with subsets of dendritic cells
    Kadowaki, N
    Antonenko, S
    Ho, S
    Rissoan, MC
    Soumelis, V
    Porcelli, SA
    Lanier, LL
    Liu, YJ
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (10) : 1221 - 1226
  • [5] NKT cells in HIV-1 infection
    Li, Demin
    Xu, Xiao-Ning
    [J]. CELL RESEARCH, 2008, 18 (08) : 817 - 822
  • [6] Mofenson L., 2006, Morbidity and Mortality Weekly Report, V55, P592
  • [7] Expansion of CD1d-restricted NKT cells in patients with primary HIV-1 infection treated with interleukin-2
    Moll, M
    Snyder-Cappione, J
    Spotts, G
    Hecht, FM
    Sandberg, JK
    Nixon, DF
    [J]. BLOOD, 2006, 107 (08) : 3081 - 3083
  • [8] CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection
    Motsinger, A
    Haas, DW
    Stanic, AK
    Van Kaer, L
    Joyce, S
    Unutmaz, D
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (07) : 869 - 879
  • [9] CD4+ T-cell immunodeficiency is more dependent on immune activation than viral load in HIV-infected children on highly active antiretroviral therapy
    Resino, Salvador
    Seoane, Elena
    Gurbindo Gutierrez, Maria Dolores
    Antonio Leon, Juan
    Angeles Munoz-Fernandez, Maria
    [J]. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2006, 42 (03) : 269 - 276
  • [10] Selective loss of innate CD4+ Vα24 natural killer T cells in human immunodeficiency virus infection
    Sandberg, JK
    Fast, NM
    Palacios, EH
    Fennelly, G
    Dobroszycki, J
    Palumbo, P
    Wiznia, A
    Grant, RM
    Bhardwaj, N
    Rosenberg, MG
    Nixon, DF
    [J]. JOURNAL OF VIROLOGY, 2002, 76 (15) : 7528 - 7534
12