CD4+ AND CD4- CD1D-RESTRICTED NATURAL KILLER T CELLS IN PERINATALLY HIV-1 INFECTED CHILDREN RECEIVING HIGHLY ACTIVE ANTIRETROVIRAL THERAPY

被引：7

作者：

Chiappini, E. ^{[1
]}

Betti, L. ^{[1
]}

Bonsignori, F. ^{[1
]}

Azzari, C. ^{[1
]}

Galli, L. ^{[1
]}

De Martino, M. ^{[1
]}

机构：

[1] Univ Florence, Dept Sci Women & Childrens Hlth, Anna Meyer Childrens Univ Hosp, I-50132 Florence, Italy

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2010年 / 23卷 / 02期

关键词：

HIV-1; infection; children; NKT cells; IMMUNODEFICIENCY-VIRUS-INFECTION; NKT CELLS; HIV-1; INFECTION; ACTIVATION; EXPANSION;

D O I：

10.1177/039463201002300232

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We conducted a cross-sectional study on 43 Italian perinatally human immunodeficiency virus-type 1 (HIV-1) infected children receiving highly active antiretroviral therapy (HAART) and 26 age-matched healthy controls to explore CD1d-restricted NKT subsets. CD4(+) CD1d-rectricted natural killer (NKT) cell depletion was evidenced in 26 HIV-1 infected children with active viral replication despite HAART. Conversely, no alteration was evidenced in 17 children with undetectable viral load, suggesting full recovery in both CDC and CD4(-) CD1d-rectricted NKT cell subsets. The loss of CD4(+) NKT cells in unresponsive children may have clinical consequences, including autoimmune disorders or cancer development. Future therapeutic perspectives are suggested.

引用

收藏

页码：665 / 669

页数：5

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