Design and synthesis of novel cytotoxic podophyllotoxin derivatives

被引：9

作者：

Xi, Wen Li ^{[4
]}

Cai, Qian ^{[4
]}

Tang, Yan Bo ^{[1
,2
,3
]}

Sun, Hua ^{[1
,2
,3
]}

Xiao, Zhi Yan ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Med Sci, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[3] Peking Union Med Coll, Beijing 100050, Peoples R China

[4] Liaoning Univ Tradit Chinese Med, Sch Pharm, Dalian 116600, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 10期

关键词：

Podophyllotoxin; C4-derivation; Cytotoxicity; ANTITUMOR AGENTS; INHIBITORS;

D O I：

10.1016/j.cclet.2010.03.040

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In order to investigate the effect of different C4 linkage moieties on the cytotoxicity of podophyllotoxin derivatives, novel 4-N-and 4-C-substituted 4'-O-demethylepipodophyllotoxin derivatives were designed and synthesized. All the compounds were tested against A549 and MCF-7 tumor cells in vitro, and six compounds showed significant cytotoxicity. The most active compound 9f was superior to GL-331, and exhibited potent cytotoxicity with IC50 value at 10(-7) mol/L level. (C) 2010 Zhi Yan Xiao. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：1153 / 1156

页数：4

共 6 条

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