The Jak-STAT Target Chinmo Prevents Sex Transformation of Adult Stem Cells in the Drosophila Testis Niche

被引：33

作者：

Ma, Qing ^{[1
]}

Wawersik, Matthew ^{[2
]}

Matunis, Erika L. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Cell Biol, Baltimore, MD 21205 USA

[2] Coll William & Mary, Dept Biol, Williamsburg, VA 23185 USA

来源：

DEVELOPMENTAL CELL | 2014年 / 31卷 / 04期

关键词：

SELF-RENEWAL; GENE-EXPRESSION; SOMATIC CONTROL; GERM-LINE; PROLIFERATION; MAINTENANCE; EVOLUTION; PROTEINS; IDENTITY; HEDGEHOG;

D O I：

10.1016/j.devcel.2014.10.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Local signals maintain adult stem cells in many tissues. Whether the sexual identity of adult stem cells must also be maintained was not known. In the adult Drosophila testis niche, local Jak-STAT signaling promotes somatic cyst stem cell (CySC) renewal through several effectors, including the putative transcription factor Chronologically inappropriate morphogenesis (Chinmo). Here, we find that Chinmo also prevents feminization of CySCs. Chinmo promotes expression of the canonical male sex determination factor DoublesexM (Dsx(M)) within CySCs and their progeny, and ectopic expression of DsxM in the CySC lineage partially rescues the chinmo sex transformation phenotype, placing Chinmo upstream of Dsx(M). The Dsx homolog DMRT1 prevents the male-to-female conversion of differentiated somatic cells in the adult mammalian testis, but its regulation is not well understood. Our work indicates that sex maintenance occurs in adult somatic stem cells and that this highly conserved process is governed by effectors of niche signals.

引用

页码：474 / 486

页数：13

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