Clinical usefulness of serum pepsinogen II in the management of Helicobacter pylori infection

被引:21
|
作者
Di Mario, F
Moussa, AM
Cavallaro, LG
Caruana, P
Merli, R
Bertolini, S
Iori, V
Cavestro, GM
Dal Bò, N
Pilotto, A
Franzé, A
Leandro, G
机构
[1] Univ Parma, Chair Gastroenterol, Dept Clin Sci, IT-43100 Parma, Italy
[2] Chair Pathol, Parma, Italy
[3] Gastroenterol Unit, Treviso, Italy
[4] Casa Sollievo Sofferenza, Geriatr Unit, San Giovanni Rotondo, Italy
[5] Gastroenterol Unit, Parma, Italy
[6] Gastroenterol Unit, Castellana Grotte, Italy
关键词
Helicobacter pylori; serum pepsinogen II; H; pylori; eradication therapy;
D O I
10.1159/000081517
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Serum pepsinogen II (sPGII) levels are known to increase during Helicobacter pylori infection. Aim: To assess H. pylori infection and success of H. pylori therapy by means of sPGII levels. Methods: sPGII levels were determined in 156 H. pylori-positive and 157 H. pylori-negative consecutive patients with dyspeptic symptoms. Additionally, sPGII determination was performed in 70 H. pylori-positive patients 2 months after H. pylori eradication therapy. In 29 of these 70 patients, gastroscopy was performed to evaluate the effect of H. pylori therapy on gastric activity. Results: H. pylori-positive subjects demonstrated a significantly higher mean of sPGII levels than H. pylori-negative subjects (16.8 +/- 7.4 vs. 8.6 +/- 3.7 mug/l; p < 0.001). The best sPGII cut-off for predicting H. pylori infection was 9.93 mu g/l (sensitivity 83%, specificity 73%). The best cut-off values to evaluate success of therapy were: sPGII of 9.47 mu g/l, a sPGII variation level (difference between baseline and after therapy) of 4.54 mu g/l, and a sPGII Delta value (sPGII variation divided by sPGII before therapy) of 25% (sensitivity 93%, specificity 91%). Conclusions: sPGII levels may be used as a reliable marker of H. pylori infection in the initial diagnosis as well as to evaluate H. pylori eradication and subsequent changes in gastric inflammation. Copyright (C) 2004 S. Karger AG, Basel.
引用
收藏
页码:167 / 172
页数:6
相关论文
共 50 条
  • [1] Clinical usefulness of serum pepsinogen II in the management of H. pylori infection
    Curlo, M.
    Iori, A.
    Guida, L.
    Cavallaro, L.
    Dal Bo, N.
    Rugge, M.
    Franze, A.
    Di Mario, F.
    HELICOBACTER, 2008, 13 (05) : 449 - 449
  • [2] Pepsinogen II in gastritis and Helicobacter pylori infection
    Di Mario, Francesco
    Crafa, Pellegrino
    Barchi, Alberto
    Franzoni, Lorella
    Franceschi, Marilisa
    Russo, Michele
    Bricca, Ludovica
    Brozzi, Lorenzo
    Castro, Kryssia Rodriguez
    Rugge, Massimo
    HELICOBACTER, 2022, 27 (02)
  • [3] Usefulness of serum pepsinogen C in evaluating Helicobacter pylori (Hp) eradication
    Ferrana, M
    Vianello, F
    Basso, D
    Kusstatscher, S
    Leandro, G
    Salandin, S
    Grasso, GA
    DalBo, N
    Battaglia, G
    Plebani, M
    Vignen, S
    DiMaric, F
    GASTROENTEROLOGY, 1996, 110 (04) : A107 - A107
  • [4] Serum pepsinogen and Helicobacter pylori infection—a Japanese population study
    K. Toyoda
    N. Furusyo
    T. Ihara
    H. Ikezaki
    Y. Urita
    J. Hayashi
    European Journal of Clinical Microbiology & Infectious Diseases, 2012, 31 : 2117 - 2124
  • [5] Relationship between serum pepsinogen levels and Helicobacter pylori infection
    Kitahara, F
    Kanai, T
    Takayama, I
    Yoda, Y
    Kobayashi, K
    Sato, T
    Kojima, Y
    Morozumi, A
    Fujino, MA
    Otsuka, K
    GASTROENTEROLOGY, 1997, 112 (04) : A176 - A176
  • [6] Endoscopic gastritis, serum pepsinogen assay, and Helicobacter pylori infection
    Lee, Sun-Young
    KOREAN JOURNAL OF INTERNAL MEDICINE, 2016, 31 (05): : 835 - 844
  • [7] Study of the usefulness of measurement of serum pepsinogen in eradication therapy of Helicobacter pylori.
    Iwasaki, A
    Nakajima, N
    Ushiyama, H
    Kato, K
    Kawamura, Y
    Kawamura, F
    Arakawa, Y
    GASTROENTEROLOGY, 1998, 114 (04) : A159 - A159
  • [8] Serum pepsinogen and Helicobacter pylori infection-a Japanese population study
    Toyoda, K.
    Furusyo, N.
    Ihara, T.
    Ikezaki, H.
    Urita, Y.
    Hayashi, J.
    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2012, 31 (09) : 2117 - 2124
  • [9] Serum gastrin and pepsinogen I, II concentrations in children with Helicobacter pylori infection: the role of CagA and VacA
    Kim, JW
    Chung, KS
    YONSEI MEDICAL JOURNAL, 1998, 39 (02) : 159 - 165
  • [10] Acid secretion, serum pepsinogen A and Helicobacter pylori
    Testino, G
    Sumberaz, A
    Cheli, R
    ITALIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1997, 29 (01): : 81 - 81