Acute in vitro effects of dronedarone, an iodine-free derivative, and amiodarone, on the rabbit sinoatrial node automaticity: A comparative study

被引:15
作者
Celestino, Daniela [1 ]
Medei, Emiliano [1 ]
Moro, Sandra [1 ]
Elizari, Marcelo V. [1 ]
Sicouri, Serge [1 ]
机构
[1] Hosp Ramos Mejia, Lab Electrofisiol Celular, Div Cardiol, Buenos Aires, DF, Argentina
关键词
antiarrhythmic drugs; in vitro study; sinus node; automaticity;
D O I
10.1177/1074248407303225
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Amiodarone is a potent antiarrhythmic drug commonly used in the treatment of supraventricular and ventricular arrhythmias. Dronedarone is a recently developed iodine-free compound (Sanofi Recherche), structurally related to amiodarone. Amiodarone and dronedarone have shown similar long-term effects on sinoatrial node automaticity in vivo and in vitro in the rabbit heart. In the present study, we used a microelectrode technique to compare the acute in vitro electrophysiologic effects of amiodarone (100 mu M) and dronedarone (100 mu M) on the rabbit sinus node. Like amiodarone, dronedarone induces a marked reduction in sinus node automaticity, evidenced by decreases in spontaneous beating rate, action potential amplitude, and slope of phase 4 depolarization. Isoproterenol dose-dependently increases sinus node automaticity in the presence of either amiodarone or dronedarone. The data suggest that dronedarone may be a useful antiarrhythmic alternative to amiodarone in the treatment of supraventricular arrhythmias.
引用
收藏
页码:248 / 257
页数:10
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