Carbon nanohorns as anticancer drug carriers

被引：347

作者：

Ajima, Kumiko ^{[1
]}

Yudasaka, Masako ^{[1
]}

Murakami, Tatsuya ^{[2
]}

Maigne, Alan ^{[1
,3
]}

Shiba, Kiyotaka ^{[4
]}

Ijima, Sumio ^{[1
,5
]}

机构：

[1] NEC Corp Ltd, JST SORST, Tsukuba, Ibaraki 3058501, Japan

[2] Japanese Fdn Canc Res, Inst Canc, JST SORST, Dept Prot Engn, Tokyo 1708455, Japan

[3] CNRS, Phys Solides Lab, UMR 8502, F-91405 Orsay, France

[4] Japanese Fdn Canc Res, Inst Canc, Dept Prot Engn, Tokyo 1708455, Japan

[5] Meijo Univ, Tenpaku Ku, Nagoya, Aichi 4688502, Japan

来源：

MOLECULAR PHARMACEUTICS | 2005年 / 2卷 / 06期

关键词：

carbon nanotube; carbon nanohorn; anticancer drug; drug carrier; cisplatin;

D O I：

10.1021/mp0500566

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We demonstrate that oxidized single-wall carbon nanohorns (SWNHs), a type of single-wall nanotube, entrap cisplatin, an anticancer agent. We found that the cisplatin structure was maintained inside the SWNHs and that the cisplatin was slowly released from the SWNHs in aqueous environments. The released cisplatin was effective in terminating the growth of human lung-cancer cells, while the SWNHs themselves had no such effect. Cisplatin-incorporated oxidized SWNHs are thus a potential drug delivery system.

引用

页码：475 / 480

页数：6

共 31 条

[1] Material storage mechanism in porous nanocarbon [J].

Ajima, K ;

Yudasaka, M ;

Suenaga, K ;

Kasuya, D ;

Azami, T ;

Iijima, S .

ADVANCED MATERIALS, 2004, 16 (05) :397-+

[2] Drug delivery systems: Entering the mainstream [J].

Allen, TM ;

Cullis, PR .

SCIENCE, 2004, 303 (5665) :1818-1822

[3] Liposomal drug formulations - Rationale for development and what we can expect for the future [J].

Allen, TM .

DRUGS, 1998, 56 (05) :747-756

[4] ACTIVATION OF PROGRAMMED CELL-DEATH (APOPTOSIS) BY CISPLATIN, OTHER ANTICANCER DRUGS, TOXINS AND HYPERTHERMIA [J].

BARRY, MA ;

BEHNKE, CA ;

EASTMAN, A .

BIOCHEMICAL PHARMACOLOGY, 1990, 40 (10) :2353-2362

[5]

BEARDEN JA, 1964, NYO10586 US AT EN CO, P533

[6] Nanocapsules: lipid-coated aggregates of cisplatin with high cytotoxicity [J].

Burger, KNJ ;

Staffhorst, RWHM ;

de Vijlder, HC ;

Velinova, MJ ;

Bomans, PH ;

Frederik, PM ;

de Kruijff, B .

NATURE MEDICINE, 2002, 8 (01) :81-84

[7] Cisplatin: From DNA damage to cancer chemotherapy [J].

Cohen, SM ;

Lippard, SJ .

PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 67, 2001, 67 :93-130

[8] INTERSTRAND CROSS-LINKS AND SEQUENCE SPECIFICITY IN THE REACTION OF CIS-DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) WITH DNA [J].

EASTMAN, A .

BIOCHEMISTRY, 1985, 24 (19) :5027-5032

[9] REEVALUATION OF INTERACTION OF CIS-DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) WITH DNA [J].

EASTMAN, A .

BIOCHEMISTRY, 1986, 25 (13) :3912-3915

[10]

Egerton R. F., 1996, ELECT ENERGY LOSS SP, P279

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