Analysis of quinolinequinone reactivity, cytotoxicity, and anti-HIV-1 properties

被引：19

作者：

Alfadhli, Ayna ^{[1
]}

Mack, Andrew ^{[1
]}

Harper, Logan ^{[1
]}

Berk, Sam ^{[1
]}

Ritchie, Christopher ^{[1
]}

Barklis, Eric ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2016年 / 24卷 / 21期

关键词：

HIV; Virus; Quinolinequinone; GAG PROTEIN INTERACTIONS; ANTITUMOR AGENTS; CAPSID PROTEIN; HIV-1; DERIVATIVES; INHIBITORS; RELEASE; BINDING; RNA; SPECTROSCOPY;

D O I：

10.1016/j.bmc.2016.09.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have analyzed a set of quinolinequinones with respect to their reactivities, cytotoxicities, and anti HIV-1 properties. Most of the quinolinequinones were reactive with glutathione, and several acted as sulfhydryl crosslinking agents. Quinolinequinones inhibited binding of the HIV-1 matrix protein to RNA to varying degrees, and several quinolinequinones showed the capacity to crosslink HIV-1 matrix proteins in vitro, and HIV-1 structural proteins in virus particles. Cytotoxicity assays yielded quinolinequinone CC50 values in the low micromolar range, reducing the potential therapeutic value of these compounds. However, one compound, 6,7-dichloro-5,8-quinolinequinone potently inactivated HIV-1, suggesting that quinolinequinones may prove useful in the preparation of inactivated virus vaccines or for other virucidal purposes. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：5618 / 5625

页数：8

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