Chiral selector with multiple hydrogen-bonding sites in a macrocyclic cavity

被引：32

作者：

Ema, Tadashi ^{[1
]}

Tanida, Daisuke ^{[1
]}

Sugita, Kyoko ^{[1
]}

Sakai, Takashi ^{[1
]}

Miyazawa, Ken-ichiro ^{[2
,3
]}

Ohnishi, Atsushi ^{[2
,3
]}

机构：

[1] Okayama Univ, Grad Sch Nat Sci & Technol, Div Chem & Biochem, Okayama 7008530, Japan

[2] Daicel Chem Ind Ltd, CPI Co, Niigata 9448550, Japan

[3] Daicel Chem Ind Ltd, CPI Co, Himeji, Hyogo 6711283, Japan

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 12期

关键词：

D O I：

10.1021/ol800940j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral macrocycles with the hydrogen bond donor/acceptor sites in the cavity were synthesized and covalently bonded to silica gel to give chiral stationary phases (CSPs), which showed excellent abilities to resolve various chiral compounds, such as benzoin and Co(acaC)(3), in HPLC. Various organic solvents could be used as the mobile phase to optimize the resolution efficiency of CSPs, and in some cases, even MeCN, MeOH, and CO2 could be used for the complete resolution of enantiomers.

引用

页码：2365 / 2368

页数：4

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