Benralizumab - a humanized mAb to IL-5Rα with enhanced antibody-dependent cell-mediated cytotoxicity - a novel approach for the treatment of asthma

被引：152

作者：

Ghazi, Aasia ^{[1
]}

Trikha, Anita ^{[1
]}

Calhoun, William J. ^{[1
]}

机构：

[1] Univ Texas Med Branch, Div Allergy & Clin Immunol, Galveston, TX 77555 USA

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2012年 / 12卷 / 01期

基金：

美国国家卫生研究院;

关键词：

asthma; benralizumab; IL-5; IL-5R alpha; MEDI-563; RECEPTOR-ALPHA CHAIN; IL-5; RECEPTOR; MEPOLIZUMAB; ANTI-INTERLEUKIN-5; EOSINOPHILS; MEDI-563; SUBUNIT;

D O I：

10.1517/14712598.2012.642359

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Introduction: Benralizumab is a monoclonal antibody that binds the a subunit of the receptor to IL-5. As IL-5 is implicated in disease states that are mediated by eosinophils, benralizumab is an attractive option for use in the management of asthma. As a result of enhanced antibody-directed cell cytotoxicity, it has enhanced eosinophil-depleting activity as compared with neutralizing monoclonal antibody directed against IL-5. Areas covered: This review presents the available data on benralizumab, including pharmacodynamics, pharmacokinetics, preclinical data and relevant clinical studies. Expert opinion: Our review indicates that although further investigation is necessary to demonstrate clinical benefit, benralizumab remains a promising treatment modality.

引用

页码：113 / 118

页数：6

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