Benralizumab - a humanized mAb to IL-5Rα with enhanced antibody-dependent cell-mediated cytotoxicity - a novel approach for the treatment of asthma

被引：152
作者：
Ghazi, Aasia [1 ]
Trikha, Anita [1 ]
Calhoun, William J. [1 ]
机构：
[1] Univ Texas Med Branch, Div Allergy & Clin Immunol, Galveston, TX 77555 USA
来源：
EXPERT OPINION ON BIOLOGICAL THERAPY | 2012年 / 12卷 / 01期
基金：
美国国家卫生研究院;
关键词：
asthma; benralizumab; IL-5; IL-5R alpha; MEDI-563; RECEPTOR-ALPHA CHAIN; IL-5; RECEPTOR; MEPOLIZUMAB; ANTI-INTERLEUKIN-5; EOSINOPHILS; MEDI-563; SUBUNIT;
D O I：
10.1517/14712598.2012.642359
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Introduction: Benralizumab is a monoclonal antibody that binds the a subunit of the receptor to IL-5. As IL-5 is implicated in disease states that are mediated by eosinophils, benralizumab is an attractive option for use in the management of asthma. As a result of enhanced antibody-directed cell cytotoxicity, it has enhanced eosinophil-depleting activity as compared with neutralizing monoclonal antibody directed against IL-5. Areas covered: This review presents the available data on benralizumab, including pharmacodynamics, pharmacokinetics, preclinical data and relevant clinical studies. Expert opinion: Our review indicates that although further investigation is necessary to demonstrate clinical benefit, benralizumab remains a promising treatment modality.
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收藏
页码：113 / 118
页数：6
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