Lopinavir/ritonavir did not shorten the duration of SARS CoV-2 shedding in patients with mild pneumonia in Taiwan

被引:44
作者
Cheng, Chien-Yu [1 ,2 ]
Lee, Yu-Lin [3 ]
Chen, Cheng-Pin [1 ,4 ]
Lin, Yi-Chun [1 ]
Liu, Chun-Eng [3 ]
Liao, Chia-Hung [5 ]
Cheng, Shu-Hsing [1 ,6 ]
机构
[1] Minist Hlth & Welf, Taoyuan Gen Hosp, Dept Internal Med, Div Infect Dis, Taoyuan, Taiwan
[2] Natl Yang Ming Univ, Sch Publ Hlth, Taipei, Taiwan
[3] Changhua Christian Hosp, Dept Internal Med, Changhua, Taiwan
[4] Natl Yang Ming Univ, Inst Clin Med, Taipei, Taiwan
[5] Minist Hlth & Welf, Nantou Hosp, Dept Internal Med, Taoyuan, Taiwan
[6] Taipei Med Univ, Sch Publ Hlth, Taipei, Taiwan
关键词
COVID-19; SARS CoV-2; Lopinavir/ritonavir (LPV/r); Shedding; THERAPEUTIC-EFFICACY; COMBINATION; RITONAVIR; LOPINAVIR;
D O I
10.1016/j.jmii.2020.03.032
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
An increase of Ct values was 0.9 per day in 2 cases of COVID-19 treated with lopinavir/ritonavir (LPV/r), an increase was 1.0 per day in 3 cases without LPV/r through illness day 1-10, indicating that LPV/r did not shorten the duration of SARS CoV-2 shedding. Copyright (C) 2020, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.
引用
收藏
页码:488 / 492
页数:5
相关论文
共 17 条
[1]  
[Anonymous], 2020, DIAGNOSTIC DETECTION
[2]   Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial [J].
Arabi, Yaseen M. ;
Alothman, Adel ;
Balkhy, Hanan H. ;
Al-Dawood, Abdulaziz ;
AlJohani, Sameera ;
Al Harbi, Shmeylan ;
Kojan, Suleiman ;
Al Jeraisy, Majed ;
Deeb, Ahmad M. ;
Assiri, Abdullah M. ;
Al-Hameed, Fahad ;
AlSaedi, Asim ;
Mandourah, Yasser ;
Almekhlafi, Ghaleb A. ;
Sherbeeni, Nisreen Murad ;
Elzein, Fatehi Elnour ;
Memon, Javed ;
Taha, Yusri ;
Almotairi, Abdullah ;
Maghrabi, Khalid A. ;
Qushmaq, Ismael ;
Al Bshabshe, Ali ;
Kharaba, Ayman ;
Shalhoub, Sarah ;
Jose, Jesna ;
Fowler, Robert A. ;
Hayden, Frederick G. ;
Hussein, Mohamed A. .
TRIALS, 2018, 19
[3]   Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation [J].
Bernardo, Maria Ester ;
Fibbe, Willem E. .
CELL STEM CELL, 2013, 13 (04) :392-402
[4]  
Cao B, 2020, NEW ENGL J MED, V382, P1787, DOI [10.1056/NEJMoa2001282, 10.1056/NEJMc2008043]
[5]   Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset [J].
Chan, Jasper Fuk-Woo ;
Yao, Yanfeng ;
Yeung, Man-Lung ;
Deng, Wei ;
Bao, Linlin ;
Jia, Lilong ;
Li, Fengdi ;
Xiao, Chong ;
Gao, Hong ;
Yu, Pin ;
Cai, Jian-Piao ;
Chu, Hin ;
Zhou, Jie ;
Chen, Honglin ;
Qin, Chuan ;
Yuen, Kwok-Yung .
JOURNAL OF INFECTIOUS DISEASES, 2015, 212 (12) :1904-1913
[6]   Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings [J].
Chu, CM ;
Cheng, VCC ;
Hung, IFN ;
Wong, MML ;
Chan, KH ;
Chan, KS ;
Kao, RYT ;
Poon, LLM ;
Wong, CLP ;
Guan, Y ;
Peiris, JSM ;
Yuen, KY .
THORAX, 2004, 59 (03) :252-256
[7]  
Gautret P, 2020, INT J ANTIMICROB AG, V56, DOI [10.1016/j.ijantimicag.2020.105949, 10.1016/j.ijantimicag.2020.106063]
[8]  
Groneberg DA, 2005, LANCET INFECT DIS, V5, P147, DOI 10.1016/S1473-3099(05)70022-0
[9]  
Holshue ML., 2020, NEW ENGL J MED, V382, P929, DOI DOI 10.1056/NEJMoa2001191
[10]   Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Facts and myths [J].
Lai, Chih-Cheng ;
Liu, Yen Hung ;
Wang, Cheng-Yi ;
Wang, Ya-Hui ;
Hsueh, Shun-Chung ;
Yen, Muh-Yen ;
Ko, Wen-Chien ;
Hsueh, Po-Ren .
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, 2020, 53 (03) :404-412