共 44 条
The HIV-1 repeated sequence R as a robust hot-spot for copy-choice recombination
被引:50
作者:

Moumen, A
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, CNRS, Unite Regulat Enzymat Activ Cellulaires, FRE 2364,Dept Biol Mol, F-75724 Paris 15, France

Polomack, L
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h-index: 0
机构: Inst Pasteur, CNRS, Unite Regulat Enzymat Activ Cellulaires, FRE 2364,Dept Biol Mol, F-75724 Paris 15, France

Roques, B
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h-index: 0
机构: Inst Pasteur, CNRS, Unite Regulat Enzymat Activ Cellulaires, FRE 2364,Dept Biol Mol, F-75724 Paris 15, France

Buc, H
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机构: Inst Pasteur, CNRS, Unite Regulat Enzymat Activ Cellulaires, FRE 2364,Dept Biol Mol, F-75724 Paris 15, France

Negroni, M
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h-index: 0
机构: Inst Pasteur, CNRS, Unite Regulat Enzymat Activ Cellulaires, FRE 2364,Dept Biol Mol, F-75724 Paris 15, France
机构:
[1] Inst Pasteur, CNRS, Unite Regulat Enzymat Activ Cellulaires, FRE 2364,Dept Biol Mol, F-75724 Paris 15, France
[2] Inst Pasteur, CNRS, URA 1960, F-75724 Paris 15, France
[3] CNRS, Dept Pharmacochim Mol & Struct, INSERM, U266,UMR 8600, F-75270 Paris 06, France
关键词:
D O I:
10.1093/nar/29.18.3814
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Template switching during reverse transcription is crucial for retroviral replication. While strand transfer on the terminal repeated sequence R is essential to achieve reverse transcription, template switching from internal regions of the genome (copy choice) leads to genetic recombination. We have developed an experimental system to study copy-choice recombination in vitro along the HIV-1 genome. We identify here several genomic regions, including the R sequence, where copy choice occurred at high rates. The frequency of copy choice occurring in a given region of template was strongly influenced by the surrounding sequences, an observation that suggests a pivotal role of the folding of template RNA in the process. The sequence R, instead, constituted an exception to this rule since it was a strong hot-spot for copy choice in the different sequence contexts tested. We suggest therefore that the structure of this region has been optimised during viral evolution to ensure efficient template switching independently from the sequences that might surround it.
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页码:3814 / 3821
页数:8
相关论文
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