Diastereomeric identification of neolignan rhamnosides from Trochodendron aralioides leaves by LC-SPE-NMR and circular dichroism

被引：5

作者：

Chang, Chia-Chuan ^{[1
]}

Tsai, Wen-Tsai ^{[1
]}

Chen, Chien-Kuang ^{[1
]}

Chen, Chung-Hsiung ^{[1
]}

Lee, Shoei-Sheng ^{[1
]}

机构：

[1] Natl Taiwan Univ, Sch Pharm, Taipei 10050, Taiwan

来源：

FITOTERAPIA | 2020年 / 144卷

关键词：

Trochodendron aralioides; Neolignan; Oxyneolignan; HPLC-SPE-NMR; CONSTITUENTS; GLYCOSIDES; LIGNANS; WOOD;

D O I：

10.1016/j.fitote.2019.104455

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Trochodendron aralioides is an old-existing relic plant with limited availability and only a few identified compounds. Accumulative analysis on the methanolic extract from its leaf part by LC-SPE-NMR resulted in the identification of seven new compounds, including three neolignan alpha-rhamnosides [(7R,8S)-dihydrodehydrodiconiferyl alcohol- 9-O-alpha-rhamnopyranoside (2) and 9'-O-alpha-rhamnopyranoside (3), and (7S,8R)-dehydrodiconiferyl alcohol 9'-O-alpha-rhamnopyranoside (4)], two isomeric oxyneolignan alpha-rhamnosides [(7R,8S)- (5) and (7R,8R)-icariside E-8 (6)), and (7R,8S)- (10) and (7R,8R)-icariside E-9 (11)], and two isomeric acylated fructofuranosyl mevalonolactones (13, 14), along with five known compounds (1, 7-9 and 12). The absolute configuration of the C-7 and C-8 positions for the new compounds 2-6 and 10-11 was assigned by comparison of the reported ECD spectra. Compounds 2, 3, 4, and 6 were further isolated by semi-preparative column chromatography for structure confirmation by 2D NMR spectroscopic analysis.

引用

页数：7

共 25 条

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