Redox properties of tyrosine and related molecules

被引：92
|
作者：
Warren, Jeffrey J. [1 ]
Winkler, Jay R. [1 ]
Gray, Harry B. [1 ]
机构：
[1] CALTECH, Beckman Inst, Pasadena, CA 91125 USA
来源：
FEBS LETTERS | 2012年 / 586卷 / 05期
关键词：
Electron transfer; Tyrosine; Tyrosyl radical; COUPLED ELECTRON-TRANSFER; CHARGE-TRANSFER; DRIVING-FORCE; PROTON; OXIDATION; TRYPTOPHAN; PEPTIDES; PHENOLS; POTENTIALS; CONSTANTS;
D O I：
10.1016/j.febslet.2011.12.014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Redox reactions of tyrosine play key roles in many biological processes, including water oxidation and DNA synthesis. We first review the redox properties of tyrosine (and other phenols) in small molecules and related polypeptides, then report work on (H20)/(Y48)-modified Pseudomonas aeruginosa azurin. The crystal structure of this protein (1.18 angstrom resolution) shows that H20 is strongly hydrogen bonded to Y48 (2.7-2.8 angstrom tyrosine-O to histidine-N distance). A firm conclusion is that proper tuning of the tyrosine potential by a proton-accepting base is critical for biological redox functions. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
引用
收藏
页码：596 / 602
页数：7
相关论文
共 50 条
  • [1] Redox regulation by thioredoxin and its related molecules
    Matsuo, Y
    Hirota, K
    Nakamura, H
    Yodoi, J
    DRUG NEWS & PERSPECTIVES, 2002, 15 (09) : 575 - 580
  • [2] REDOX POTENTIALS OF SOME COVALENTLY LINKED PORPHYRIN QUINONES AND RELATED MOLECULES
    WILFORD, JH
    ARCHER, MD
    BOLTON, JR
    HO, TF
    SCHMIDT, JA
    WEEDON, AC
    JOURNAL OF PHYSICAL CHEMISTRY, 1985, 89 (25): : 5395 - 5398
  • [3] REDOX ALKYLATION OF TYROSINE DERIVATIVES
    BARLOS, K
    LAMPROPOULOU, M
    MARMARAS, V
    PAPAIOANNOU, D
    PATRIANAKOU, S
    LIEBIGS ANNALEN DER CHEMIE, 1986, (08): : 1407 - 1412
  • [4] Water molecules coupled to the redox-active tyrosine YD in photosystem II as detected by FTIR Spectroscopy
    Takahashi, Ryouta
    Sugiura, Miwa
    Noguchi, Takumi
    BIOCHEMISTRY, 2007, 46 (49) : 14245 - 14249
  • [5] Antitumor Properties of Natural Compounds and Related Molecules
    Robles-Fernandez, Inmaculada
    Rodriguez-Serrano, Fernando
    Alvarez, Pablo J.
    Ortiz, Raul
    Rama, Ana R.
    Prados, Jose
    Melguizo, Consolacion
    Alvarez-Manzaneda, Enrique
    Aranega, Antonia
    RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY, 2013, 8 (03) : 203 - 215
  • [6] Properties of molecules closely related to vacuum technology
    Fukutani K.
    Ogura S.
    Ohno S.
    J.Vac. Soc.Japan, 6 (145-155): : 145 - 155
  • [7] THE DIELECTRIC PROPERTIES OF SOME QUINONES AND RELATED MOLECULES
    SOUNDARARAJAN, S
    VOLD, MJ
    TRANSACTIONS OF THE FARADAY SOCIETY, 1958, 54 (08): : 1155 - 1159
  • [8] Thermal and magnetic properties of coronene and related molecules
    Schulman, JM
    Disch, RL
    JOURNAL OF PHYSICAL CHEMISTRY A, 1997, 101 (48): : 9176 - 9179
  • [9] REDOX PROPERTIES OF METALHEXACYANIDE ANIONS COMPLEXED BY MACROCYCLIC POLYAMMONIUM RECEPTOR MOLECULES
    PETER, F
    GROSS, M
    HOSSEINI, MW
    LEHN, JM
    JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 1983, 144 (1-2) : 279 - 292
  • [10] Redox properties of tea polyphenols and related biological activities
    Sang, SM
    Hou, Z
    Lambert, JD
    Yang, CS
    ANTIOXIDANTS & REDOX SIGNALING, 2005, 7 (11-12) : 1704 - 1714
12345