Molecular Mechanisms of Barrett's Esophagus

被引：29
作者：
Chen, Hao [1 ]
Fang, Yu [1 ,2 ]
Tevebaugh, Whitney [1 ]
Orlando, Roy C. [3 ]
Shaheen, Nicholas J. [3 ]
Chen, Xiaoxin [1 ]
机构：
[1] N Carolina Cent Univ, Canc Res Program, Julius L Chambers Biomed Biotechnol Res Inst, Durham, NC 27707 USA
[2] Cent S Univ, Xiangya Hosp 2, Dept Cardiac & Thorac Surg, Changsha 410011, Hunan, Peoples R China
[3] Univ N Carolina, Div Gastroenterol & Hepatol, Ctr Esophageal Dis & Swallowing, Chapel Hill, NC 27599 USA
来源：
DIGESTIVE DISEASES AND SCIENCES | 2011年 / 56卷 / 12期
关键词：
Barrett's esophagus; Transcription factor; Signaling pathway; HOMEOBOX GENE CDX2; HEPATOCYTE NUCLEAR FACTOR-1-ALPHA; GASTRIC EPITHELIAL-CELLS; NF-KAPPA-B; DYSPLASIA-ADENOCARCINOMA SEQUENCE; GATA TRANSCRIPTION FACTORS; HOMEODOMAIN PROTEIN CDX2; MESSENGER-RNA EXPRESSION; NOTCH SIGNALING PATHWAY; GUANYLYL CYCLASE-C;
D O I：
10.1007/s10620-011-1885-6
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Barrett's esophagus (BE) is defined as the metaplastic conversion of esophageal squamous epithelium to intestinalized columnar epithelium. As a premalignant lesion of esophageal adenocarcinoma (EAC), BE develops as a result of chronic gastroesophageal reflux disease (GERD). Many studies have been conducted to understand the molecular mechanisms of this disease. This review summarizes recent results involving squamous and intestinal transcription factors, signaling pathways, stromal factors, microRNAs, and other factors in the development of BE. A conceptual framework is proposed to guide future studies. We expect elucidation of the molecular mechanisms of BE to help in the development of improved management of GERD, BE, and EAC.
引用
收藏
页码：3405 / 3420
页数：16
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