Is there any therapeutic value for the use of histone deacetylase inhibitors for chronic pain?

被引：21

作者：

Wang, Wei ^{[1
]}

Cui, Shan-shan ^{[2
]}

Lu, Rui ^{[1
]}

Zhang, Hui ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Sch Stomatol, Dept Anesthesiol, State Key Lab Mil Stomatol, Xian 710032, Peoples R China

[2] Wuhan Univ, Zhongnan Hosp, Dept Anesthesiol, East Lake Rd, Wuhan 430071, Peoples R China

来源：

BRAIN RESEARCH BULLETIN | 2016年 / 125卷

基金：

中国国家自然科学基金;

关键词：

Chronic pain; Histone deacetylases; Epigenetic; Inhibitors; CHRONIC CONSTRICTION INJURY; PERIPHERAL-NERVE INJURY; OPIOID-INDUCED HYPERALGESIA; CPG-BINDING PROTEIN-2; NEUROPATHIC PAIN; VALPROIC ACID; EPIGENETIC REGULATION; HDAC INHIBITORS; SPINAL-CORD; PERSISTENT PAIN;

D O I：

10.1016/j.brainresbull.2016.04.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chronic pain is a complex clinical condition that reduces the quality of life for billions of people. In recent years, the role of epigenetic modulation in the control of long-term neuronal plasticity has attracted the attention of pain researchers. The epigenetic mechanisms include covalent modifications of DNA and/or histone proteins. Mounting evidence suggests that the activity of histone deacetylases (HDACs) and levels of histone acetylation are dynamic and that these enzymes modulate pain-related synaptic plasticity. Therefore, HDACs play essential roles in chronic pain development and maintenance. In this mini review, we will discuss the role of HDACs in the pathogenesis of chronic pain and will consider the therapeutic value of HDAC inhibitors in treating chronic pain. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：44 / 52

页数：9

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