Is there any therapeutic value for the use of histone deacetylase inhibitors for chronic pain?

被引：21
作者：
Wang, Wei [1 ]
Cui, Shan-shan [2 ]
Lu, Rui [1 ]
Zhang, Hui [1 ]
机构：
[1] Fourth Mil Med Univ, Sch Stomatol, Dept Anesthesiol, State Key Lab Mil Stomatol, Xian 710032, Peoples R China
[2] Wuhan Univ, Zhongnan Hosp, Dept Anesthesiol, East Lake Rd, Wuhan 430071, Peoples R China
来源：
BRAIN RESEARCH BULLETIN | 2016年 / 125卷
基金：
中国国家自然科学基金;
关键词：
Chronic pain; Histone deacetylases; Epigenetic; Inhibitors; CHRONIC CONSTRICTION INJURY; PERIPHERAL-NERVE INJURY; OPIOID-INDUCED HYPERALGESIA; CPG-BINDING PROTEIN-2; NEUROPATHIC PAIN; VALPROIC ACID; EPIGENETIC REGULATION; HDAC INHIBITORS; SPINAL-CORD; PERSISTENT PAIN;
D O I：
10.1016/j.brainresbull.2016.04.010
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Chronic pain is a complex clinical condition that reduces the quality of life for billions of people. In recent years, the role of epigenetic modulation in the control of long-term neuronal plasticity has attracted the attention of pain researchers. The epigenetic mechanisms include covalent modifications of DNA and/or histone proteins. Mounting evidence suggests that the activity of histone deacetylases (HDACs) and levels of histone acetylation are dynamic and that these enzymes modulate pain-related synaptic plasticity. Therefore, HDACs play essential roles in chronic pain development and maintenance. In this mini review, we will discuss the role of HDACs in the pathogenesis of chronic pain and will consider the therapeutic value of HDAC inhibitors in treating chronic pain. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：44 / 52
页数：9
相关论文
共 103 条
  • [1] Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders
    Abe, Ted
    Zukin, R. Suzanne
    [J]. CURRENT OPINION IN PHARMACOLOGY, 2008, 8 (01) : 57 - 64
  • [2] Annunziato AT, 2000, GENE EXPRESSION, V9, P37
  • [3] [Anonymous], GUT
  • [4] Arany I, 2011, ANTICANCER RES, V31, P3267
  • [5] Epigenetic regulation of persistent pain
    Bai, Guang
    Ren, Ke
    Dubner, Ronald
    [J]. TRANSLATIONAL RESEARCH, 2015, 165 (01) : 177 - 199
  • [6] Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia
    Bai, Guang
    Wei, Dong
    Zou, Shiping
    Ren, Ke
    Dubner, Ronald
    [J]. MOLECULAR PAIN, 2010, 6
  • [7] Cellular and Molecular Mechanisms of Pain
    Basbaum, Allan I.
    Bautista, Diana M.
    Scherrer, Gregory
    Julius, David
    [J]. CELL, 2009, 139 (02) : 267 - 284
  • [8] The complex language of chromatin regulation during transcription
    Berger, Shelley L.
    [J]. NATURE, 2007, 447 (7143) : 407 - 412
  • [9] Why are antiepileptic drugs used for nonepileptic conditions?
    Bialer, Meir
    [J]. EPILEPSIA, 2012, 53 : 26 - 33
  • [10] Transcriptional regulation by histone modifications: towards a theory of chromatin re-organization during stem cell differentiation
    Binder, Hans
    Steiner, Lydia
    Przybilla, Jens
    Rohlf, Thimo
    Prohaska, Sonja
    Galle, Joerg
    [J]. PHYSICAL BIOLOGY, 2013, 10 (02)
12345678910