Mathematical Projection Model of Visual Loss Due to Fuchs Corneal Dystrophy

被引：15

作者：

Hatou, Shin ^{[1
]}

Shimmura, Shigeto ^{[1
]}

Shimazaki, Jun ^{[2
]}

Usui, Tomohiko ^{[3
]}

Amano, Shiro ^{[3
]}

Yokogawa, Hideaki ^{[4
]}

Kobayashi, Akira ^{[4
]}

Zheng, Xiaodong ^{[5
]}

Shiraishi, Atsushi ^{[5
]}

Ohashi, Yuichi ^{[5
]}

Inatomi, Tsutomu ^{[6
]}

Tsubota, Kazuo ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Ophthalmol, Shinjuku Ku, Tokyo 1608582, Japan

[2] Tokyo Dent Coll Ichikawa Gen Hosp, Dept Ophthalmol, Tokyo, Japan

[3] Univ Tokyo, Sch Med, Dept Ophthalmol, Tokyo 113, Japan

[4] Kanazawa Univ, Sch Med, Dept Ophthalmol, Kanazawa, Ishikawa 920, Japan

[5] Ehime Univ, Sch Med, Dept Ophthalmol, Matsuyama, Ehime, Japan

[6] Kyoto Prefectural Univ Med, Dept Ophthalmol, Kyoto, Japan

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2011年 / 52卷 / 11期

关键词：

ENDOTHELIAL-CELL LOSS; PENETRATING KERATOPLASTY; LENS IMPLANTATION; 10-YEAR PERIOD; CHAMBER LENSES; GUTTATA; CATARACT; DENSITY; PREVALENCE; MORPHOLOGY;

D O I：

10.1167/iovs.11-8040

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE. To devise a mathematical disease classification model for eyes with primary guttata cornea, on the bases of endothelial loss trajectory and probability of advanced disease. METHODS. A series of 1971 patients (3281 eyes), some with and some without guttata corneas, undergoing specular microscopy were retrospectively reviewed. The eyes were classified into four stages; stage 0, without guttae; 1, guttata cornea without edema; 2, mild Fuchs' corneal dystrophy (FCD); and 3, severe FCD, according to clinical records, and patient age and corneal endothelial cell density (ECD) were plotted. Nonparametric density smoothing was used to create a contour map, and a best-fit curve for ECD loss was calculated. The relation between ECD decrease rate and the stages were evaluated. RESULTS. Endothelial decrease rate in stage 0 was 0.44%/year, which was compatible with that of normal eyes reported in previous studies. Decrease rates of stages 1, 2, and 3 were 0.81%, 2.65%, and 3.08%/year, respectively. The age-ECD loss curves of 1.40%/year (ECO(1.4)) and 2.00%/year (ECO(2.0)) further divided stage 1 into three subgroups; stage 1a, asymptomatic guttata cornea; 1b, borderline guttata cornea; and 1c, pre-FCD. The ECO(2.0) cutoff line differentiated eyes with FCD from those without edema with a sensitivity and specificity of >90%. Stage 1c eyes were below ECO(2.0) and had a decrease rate as high as FCD. CONCLUSIONS. This mathematical model can be used to predict the prognosis of patients with primary guttata cornea. (Invest Ophthalmol Vis Sci. 2011;52:7888-7893) DOI:10.1167/iovs.11-8040

引用

页码：7888 / 7893

页数：6

共 24 条

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