Inference in Psychiatry via 2-SampleMendelian Randomization-From Association to Causal Pathway?

被引:27
作者
Byrne, Enda M. [1 ]
Yang, Jian [1 ,2 ]
Wray, Naomi R. [1 ,2 ]
机构
[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
[2] Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
基金
英国医学研究理事会;
关键词
MENDELIAN RANDOMIZATION;
D O I
10.1001/jamapsychiatry.2017.3162
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
引用
收藏
页码:1191 / 1192
页数:2
相关论文
共 10 条
  • [1] Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
    Bowden, Jack
    Smith, George Davey
    Burgess, Stephen
    [J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2015, 44 (02) : 512 - 525
  • [2] Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods
    Burgess, Stephen
    Dudbridge, Frank
    Thompson, Simon G.
    [J]. STATISTICS IN MEDICINE, 2016, 35 (11) : 1880 - 1906
  • [3] Assessing causality in associations between cannabis use and schizophrenia risk: a two-sample Mendelian randomization study
    Gage, S. H.
    Jones, H. J.
    Burgess, S.
    Bowden, J.
    Smith, G. Davey
    Zammit, S.
    Munafo, M. R.
    [J]. PSYCHOLOGICAL MEDICINE, 2017, 47 (05) : 971 - 980
  • [4] Inflammatory Biomarkers and Risk of Schizophrenia A 2-Sample Mendelian Randomization Study
    Hartwig, Fernando Pires
    Borges, Maria Carolina
    Horta, Bernardo Lessa
    Bowden, Jack
    Smith, George Davey
    [J]. JAMA PSYCHIATRY, 2017, 74 (12) : 1226 - 1233
  • [5] Detection and interpretation of shared genetic influences on 42 human traits
    Pickrell, Joseph K.
    Berisa, Tomaz
    Liu, Jimmy Z.
    Segurel, Laure
    Tung, Joyce Y.
    Hinds, David A.
    [J]. NATURE GENETICS, 2016, 48 (07) : 709 - +
  • [6] Efficient Design for Mendelian Randomization Studies: Subsample and 2-Sample Instrumental Variable Estimators
    Pierce, Brandon L.
    Burgess, Stephen
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 2013, 178 (07) : 1177 - 1184
  • [7] 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?
    Smith, GD
    Ebrahim, S
    [J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2003, 32 (01) : 1 - 22
  • [8] When Will Mendelian Randomization Become Relevant for Clinical Practice and Public Health?
    Smith, George Davey
    Paternoster, Lavinia
    Relton, Caroline
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2017, 317 (06): : 589 - 591
  • [9] Cannabis use and risk of schizophrenia: a Mendelian randomization study
    Vaucher, J.
    Keating, B. J.
    Lasserre, A. M.
    Gan, W.
    Lyall, D. M.
    Ward, J.
    Smith, D. J.
    Pell, J. P.
    Sattar, N.
    Pare, G.
    Holmes, M. V.
    [J]. MOLECULAR PSYCHIATRY, 2018, 23 (05) : 1287 - 1292
  • [10] 10 Years of GWAS Discovery: Biology, Function, and Translation
    Visscher, Peter M.
    Wray, Naomi R.
    Zhang, Qian
    Sklar, Pamela
    McCarthy, Mark I.
    Brown, Matthew A.
    Yang, Jian
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2017, 101 (01) : 5 - 22