The Role of Cyclooxygenase-2 in Colorectal Cancer

被引：101
作者：
Sheng, Juan [1 ]
Sung, Hong [2 ]
Yu, Fu-Bing [1 ]
Li, Bo [3 ]
Zhang, Yuan [4 ]
Zhu, Ying-Ting [4 ]
机构：
[1] Second Peoples Hosp Yunnan Prov, Dept Gastroenterol, Kunming 650021, Yunnan, Peoples R China
[2] Nanjing Med Univ, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China
[3] Second Peoples Hosp Yunnan Prov, Dept Gen Surg, Kunming 650021, Yunnan, Peoples R China
[4] TissueTech Inc, Miami, FL 33032 USA
来源：
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2020年 / 17卷 / 08期
关键词：
cancer; colon; cyclooxygenase-2; invasion; prostaglandin; GROWTH-FACTOR RECEPTOR; COLON-CANCER; PROGNOSTIC-SIGNIFICANCE; MEDIATES PROLIFERATION; PROSTANOID RECEPTORS; EPITHELIAL-CELLS; DOWN-REGULATION; BREAST-CANCER; COX-2; EXPRESSION;
D O I：
10.7150/ijms.44439
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Colorectal cancer is the third common cancer in this world, accounting for more than 1 million cases each year. However, detailed etiology and mechanism of colorectal cancer have not been fully understood. For example, cyclooxygenase-2 (COX-2) and its product prostaglandin E-2(PGE(2)) have been closely linked to its occurrence, progression and prognosis. However, the mechanisms on how COX-2 and PGE(2)-mediate the pathogenesis of colorectal cancer are obscure. In this review, we have summarized recent advances in studies of pathogenesis and control in colorectal cancer to assist further advances in the research for the cure of the cancer. In addition, the knowledge gained may also guide the audiences for reduction of the risk and control of this deadly disease.
引用
收藏
页码：1095 / 1101
页数：7
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