Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis

被引：34

作者：

Cosci, Alessandro ^{[1
,2
,3
,4
]}

Nogueira, Marcelo Saito ^{[4
]}

Pratavieira, Sebastiao ^{[4
]}

Takahama, Ademar, Jr. ^{[5
]}

Azevedo, Rebeca de Souza ^{[5
]}

Kurachi, Cristina ^{[4
]}

机构：

[1] Museo Storico Fis, Piazza Viminale 1, I-00184 Rome, Italy

[2] Ctr Studi & Ric Enrico Fermi, Piazza Viminale 1, I-00184 Rome, Italy

[3] CNR, Ist Fis Applicata Nello Carrara, IFAC, Via Madonna Piano 10, I-50019 Sesto Fiorentino, Italy

[4] Univ Sao Paulo, Sao Carlos Inst Phys, POB 369, BR-13560970 Sao Carlos, SP, Brazil

[5] Univ Fed Fluminense, Fac Odontol Nova Friburgo, BR-24220000 Niteroi, RJ, Brazil

来源：

BIOMEDICAL OPTICS EXPRESS | 2016年 / 7卷 / 10期

基金：

巴西圣保罗研究基金会;

关键词：

LIFETIME SPECTROSCOPY; IMAGING-SYSTEM; AUTOFLUORESCENCE; MICROSCOPY; TISSUE; NADH;

D O I：

10.1364/BOE.7.004210

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Actinic cheilitis is a potentially malignant disorder of the lips. Its first cause is believed to be UV sun radiation. The lesion is highly heterogeneous, making the choice of area to be biopsied difficult. This study exploits the capabilities of time-resolved fluorescence spectroscopy for the identification of the most representative area to be biopsied. A preliminary study was performed on fourteen patients. A classification algorithm was used on data acquired on nine different biopsies. The algorithm discriminated between absent, mild, and moderate dysplasia with a sensitivity of 92.9%, 90.0%, and 80.0%, respectively. The false positive rate for healthy tissue (specificity) was 88.8%. (C) 2016 Optical Society of America

引用

页码：4210 / 4219

页数：10

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