Glycolytic and lipid oxidative metabolic programs are essential for freshly-isolated regulatory T cells in mice with sepsis

被引：3
作者：
Zhu, Xiaomei [1 ]
Ji, WenQing [1 ]
Guo, Shubin [1 ]
Zhu, Di [1 ]
Yang, Yue [1 ]
Liu, Xin [1 ]
机构：
[1] Capital Med Univ, Beijing Lab Cardiopulm Cerebral Resuscitat, Emergency Dept, Chao Yang Hosp, Beijing 100020, Peoples R China
来源：
RSC ADVANCES | 2020年 / 10卷 / 35期
关键词：
SEPTIC SHOCK; IMMUNOSUPPRESSION; IMMUNOMETABOLISM; DIFFERENTIATION; CHECKPOINT; EXPRESSION; T(H)17;
D O I：
10.1039/d0ra01947j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Immunometabolism determines the fate and function of regulatory T cells. The metabolic phenotype of regulatory T cells (Treg) is affected by various factors. The relationship between Treg metabolism and function of mice with sepsis is not clear. We used liquid chromatography and tandem mass spectrometry (LC-MS/MS) to analyze the metabolic profiles of freshly-isolated spleen Treg cells in mice with sepsis. It was found that in severe infection, activated Treg cells depend on glycolysis and fatty acid oxidation, and inhibition of metabolic pathways has a significant impact on the number and quality of Treg cells. Understanding the metabolic characteristics of Treg cells in the real environment in the body helps to grasp the function of Treg cells and even the overall immune status. Targeting the metabolic pathway of Treg may provide a new method for the treatment of sepsis.
引用
收藏
页码：21000 / 21008
页数：9
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