Bioadhesive supramolecular hydrogel from unprotected, short d,l-peptides with Phe-Phe and Leu-Asp-Val motifs

被引：35

作者：

Cringoli, Maria Cristina ^{[1
]}

Romano, Chiara ^{[1
]}

Parisi, Evelina ^{[1
]}

Waddington, Lynne J. ^{[2
]}

Melchionna, Michele ^{[1
]}

Semeraro, Sabrina ^{[1
]}

De Zorzi, Rita ^{[1
]}

Gronholm, Mikaela ^{[3
,4
]}

Marchesan, Silvia ^{[1
]}

机构：

[1] Univ Trieste, Chem & Pharmaceut Sci Dept, Via L Giorgieri 1, I-34127 Trieste, Italy

[2] CSIRO Mfg, Clayton, Vic 3168, Australia

[3] Univ Helsinki, Mol & Integrat Biosci, Fac Biol & Environm Sci, PB 56, Helsinki 00014, Finland

[4] Univ Helsinki, Fac Pharm, Drug Res Program, PB 56, Helsinki 00014, Finland

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 20期

关键词：

PEPTIDE; MOLECULES; DESIGN;

D O I：

10.1039/c9cc09947f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The uncapped tripeptide (D)Phe-Phe-Leu acts as self-assembly template to yield supramolecular hydrogel biomaterials. As an example, self-assembling (D)Phe-Phe-Leu-Asp-Val contains the LDV bioadhesive motif for beta 1 integrin activation. Hydrogels made of the two peptides successfully mimic fibronectin of the extracellular matrix and lead to high cell viability, adhesion, and spreading.

引用

页码：3015 / 3018

页数：4

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