Is there a role for high-dose chemotherapy with stem cell rescue for brain stem tumors of childhood?

被引：24

作者：

Dunkel, IJ ^{[1
]}

OMalley, B ^{[1
]}

Finlay, JL ^{[1
]}

机构：

[1] MEM SLOAN KETTERING CANC CTR,DEPT RADIOL,NEW YORK,NY 10021

来源：

PEDIATRIC NEUROSURGERY | 1996年 / 24卷 / 05期

关键词：

brain stem tumor; chemotherapy; stem cell rescue; autologous;

D O I：

10.1159/000121049

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Diffuse pontine tumors are highly lethal and conventional therapy with irradiation provides long-term survival to a very small proportion of the patients. We have reported promising results using high-dose chemotherapy with autologous stem cell rescue in patients with recurrent high-grade astrocytomas in other anatomic locations, but our results and those of others have been very discouraging in children with brain stem tumors. Alternative strategies need to be developed for this highly lethal disease.

引用

页码：263 / 266

页数：4

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