Electrochemically Stimulated Release from Liposomes Embedded in a Polyelectrolyte Multilayer

被引：26

作者：

Graf, Norma ^{[1
,2
]}

Albertini, Francesco ^{[1
,2
]}

Petit, Tristan ^{[1
,2
]}

Reimhult, Erik ^{[3
]}

Voeroes, Janos ^{[1
,2
]}

Zambelli, Tomaso ^{[1
,2
]}

机构：

[1] Univ Zurich, Inst Biomed Engn, Lab Biosensors & Bioelect, CH-8092 Zurich, Switzerland

[2] ETH, CH-8092 Zurich, Switzerland

[3] Inst Nanobiotechnol NBT, A-1190 Vienna, Austria

来源：

ADVANCED FUNCTIONAL MATERIALS | 2011年 / 21卷 / 09期

关键词：

LAYER THIN-FILMS; PHOSPHOLIPID-VESICLES; EXPONENTIAL-GROWTH; DRUG-DELIVERY; CELL-ADHESION; ULTRASOUND; ARCHITECTURES; PRINCIPLES; STABILITY; DNA;

D O I：

10.1002/adfm.201002283

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Triggered release of an entrapped dye from vesicles embedded in a polyelectrolyte multilayer (PEM), as a consequence of the electrochemically induced local pH change in the vicinity of the electrode, is reported. The PEM was deposited on an indium tin oxide (ITO) electrode wherein lipid vesicles filled with a fluorescent dye were embedded. The use of vesicles with a strong negative charge and the polyelectrolyte species of the PEM matrix with a polycation as topmost layer enabled the generation of a stable layer of liposomes in the PEM.

引用

页码：1666 / 1672

页数：7

共 49 条

[21] Layer by layer self-assembled polyelectrolyte multilayers with embedded phospholipid vesicles [J].

Michel, M ;

Vautier, D ;

Voegel, JC ;

Schaaf, P ;

Ball, V .

LANGMUIR, 2004, 20 (12) :4835-4839

[22] Magnetoliposomes for controlled drug release in the presence of low-frequency magnetic field [J].

Nappini, Silvia ;

Bombelli, Francesca Baldelli ;

Bonini, Massimo ;

Norden, Bengt ;

Baglioni, Piero .

SOFT MATTER, 2010, 6 (01) :154-162

[23] Redox-Triggered Contents Release from Liposomes [J].

Ong, Winston ;

Yang, Yuming ;

Cruciano, Angela C. ;

McCarley, Robin L. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (44) :14739-14744

[24] Molecular basis for the explanation of the exponential growth of polyelectrolyte multilayers [J].

Picart, C ;

Mutterer, J ;

Richert, L ;

Luo, Y ;

Prestwich, GD ;

Schaaf, P ;

Voegel, JC ;

Lavalle, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :12531-12535

[25] A novel layer-by-layer approach for the fabrication of conducting polymer/RNA multilayer films for controlled release [J].

Recksiedler, CL ;

Deore, BA ;

Freund, MS .

LANGMUIR, 2006, 22 (06) :2811-2815

[26] Vesicle adsorption on SiO2 and TiO2:: Dependence on vesicle size [J].

Reimhult, E ;

Höök, F ;

Kasemo, B .

JOURNAL OF CHEMICAL PHYSICS, 2002, 117 (16) :7401-7404

[27] Improvement of stability and cell adhesion properties of polyelectrolyte multilayer films by chemical cross-linking [J].

Richert, L ;

Boulmedais, F ;

Lavalle, P ;

Mutterer, J ;

Ferreux, E ;

Decher, G ;

Schaaf, P ;

Voegel, JC ;

Picart, C .

BIOMACROMOLECULES, 2004, 5 (02) :284-294

[28] A simple setup to simultaneously measure the resonant frequency and the absolute dissipation factor of a quartz crystal microbalance [J].

Rodahl, M ;

Kasemo, B .

REVIEW OF SCIENTIFIC INSTRUMENTS, 1996, 67 (09) :3238-3241

[29] Sprayed polyelectrolyte multilayers [J].

Schlenoff, JB ;

Dubas, ST ;

Farhat, T .

LANGMUIR, 2000, 16 (26) :9968-9969

[30] Polyelectrolyte multilayers with a tunable Young's modulus:: Influence of film stiffness on cell adhesion [J].

Schneider, A ;

Francius, G ;

Obeid, R ;

Schwinté, P ;

Hemmerlé, J ;

Frisch, B ;

Schaaf, P ;

Voegel, JC ;

Senger, B ;

Picart, C .

LANGMUIR, 2006, 22 (03) :1193-1200

← 1 2 3 4 5 →