Electrochemically Stimulated Release from Liposomes Embedded in a Polyelectrolyte Multilayer

被引：26
作者：
Graf, Norma [1 ,2 ]
Albertini, Francesco [1 ,2 ]
Petit, Tristan [1 ,2 ]
Reimhult, Erik [3 ]
Voeroes, Janos [1 ,2 ]
Zambelli, Tomaso [1 ,2 ]
机构：
[1] Univ Zurich, Inst Biomed Engn, Lab Biosensors & Bioelect, CH-8092 Zurich, Switzerland
[2] ETH, CH-8092 Zurich, Switzerland
[3] Inst Nanobiotechnol NBT, A-1190 Vienna, Austria
来源：
ADVANCED FUNCTIONAL MATERIALS | 2011年 / 21卷 / 09期
关键词：
LAYER THIN-FILMS; PHOSPHOLIPID-VESICLES; EXPONENTIAL-GROWTH; DRUG-DELIVERY; CELL-ADHESION; ULTRASOUND; ARCHITECTURES; PRINCIPLES; STABILITY; DNA;
D O I：
10.1002/adfm.201002283
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Triggered release of an entrapped dye from vesicles embedded in a polyelectrolyte multilayer (PEM), as a consequence of the electrochemically induced local pH change in the vicinity of the electrode, is reported. The PEM was deposited on an indium tin oxide (ITO) electrode wherein lipid vesicles filled with a fluorescent dye were embedded. The use of vesicles with a strong negative charge and the polyelectrolyte species of the PEM matrix with a polycation as topmost layer enabled the generation of a stable layer of liposomes in the PEM.
引用
收藏
页码：1666 / 1672
页数：7
相关论文
共 49 条
  • [1] Peptide hormone covalently bound to polyelectrolytes and embedded into multilayer architectures conserving full biological activity
    Chluba, J
    Voegel, JC
    Decher, G
    Erbacher, P
    Schaaf, P
    Ogier, J
    [J]. BIOMACROMOLECULES, 2001, 2 (03) : 800 - 805
  • [2] Fuzzy nanoassemblies: Toward layered polymeric multicomposites
    Decher, G
    [J]. SCIENCE, 1997, 277 (5330) : 1232 - 1237
  • [3] Electrochemical tuning of the stability of PLL/DNA multilayers
    Dieguez, Lorena
    Darwish, Nasser
    Graf, Norma
    Voeroes, Janos
    Zambelli, Tomaso
    [J]. SOFT MATTER, 2009, 5 (12) : 2415 - 2421
  • [4] Thin polymer layers formed by polyelectrolyte multilayer techniques on biological surfaces
    Elbert, DL
    Herbert, CB
    Hubbell, JA
    [J]. LANGMUIR, 1999, 15 (16) : 5355 - 5362
  • [5] Influence of applied currents on the viability of cells close to microelectrodes
    Gabi, Michael
    Sannomiya, Takumi
    Larmagnac, Alexandre
    Puttaswamy, Manjunath
    Voeroes, Janos
    [J]. INTEGRATIVE BIOLOGY, 2009, 1 (01) : 108 - 115
  • [6] Characterization of a proton pumping transmembrane protein incorporated into a supported three-dimensional matrix of proteoliposomes
    Graneli, Annette
    Benkoski, Jason J.
    Hook, Fredrik
    [J]. ANALYTICAL BIOCHEMISTRY, 2007, 367 (01) : 87 - 94
  • [7] Electrochemical biosensors -: Sensor principles and architectures
    Grieshaber, Dorothee
    MacKenzie, Robert
    Voeroes, Janos
    Reimhult, Erik
    [J]. SENSORS, 2008, 8 (03) : 1400 - 1458
  • [8] Swelling and Contraction of Ferrocyanide-Containing Polyelectrolyte Multilayers upon Application of an Electric Potential
    Grieshaber, Dorothee
    Voeroes, Janos
    Zambelli, Tomaso
    Ball, Vincent
    Schaaf, Pierre
    Voegel, Jean-Claude
    Boulmedais, Fouzia
    [J]. LANGMUIR, 2008, 24 (23) : 13668 - 13676
  • [9] Polyelectrolyte coatings with a potential for electronic control and cell sheet engineering
    Guillaume-Gentil, Orane
    Akiyama, Yoshikatsu
    Schuler, Martin
    Tang, Clarence
    Textor, Marcus
    Yamato, Masayuki
    Okano, Teruo
    Voeroes, Janos
    [J]. ADVANCED MATERIALS, 2008, 20 (03) : 560 - +
  • [10] Global and local view on the electrochemically induced degradation of polyelectrolyte multilayers: from dissolution to delamination
    Guillaume-Gentil, Orane
    Graf, Norma
    Boulmedais, Fouzia
    Schaaf, Pierre
    Voeroes, Janos
    Zambelli, Tomaso
    [J]. SOFT MATTER, 2010, 6 (17) : 4246 - 4254
12345