SYNTHESIS OF 1-DEOXYELDECALCITOL, A BIOLOGICALLY INTERESTING ANALOG OF 1α,25-DIHYDROXY-2β-(3-HYDROXYPROPOXY)VITAMIN D3 (ELDECALCITOL)

被引：3

作者：

Sasaki, Hirotaka ^{[1
]}

Eto, Kohei ^{[1
]}

Takahashi, Keisuke ^{[1
]}

Ishihara, Jun ^{[1
]}

Hatakeyama, Susumi ^{[1
]}

Kubodera, Noboru ^{[2
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 8528521, Japan

[2] Chugai Pharmaceut Co Ltd, Chuo Ku, Tokyo 1038324, Japan

来源：

HETEROCYCLES | 2011年 / 83卷 / 06期

关键词：

Calcitriol; Calcifediol; Eldecalcitol; 1-Deoxyeldecalcitol; Trost's Coupling Methodology; BONE-MINERAL LOSS; VITAMIN-D ANALOGS; OVARIECTOMIZED RATS; ED-71; DIASTEREOMER; CALCIUM; DERIVATIVES;

D O I：

10.3987/COM-11-12189

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of biologically interesting 1-deoxyeldecalcitol, a dehydroxylated analog at the la-position of 1 alpha,25-dihydroxy-2 beta-(3-hydroxypropoxy)vitamin D-3 (eldecalcitol), using Trost's coupling methodology is described.

引用

页码：1385 / 1394

页数：10

共 25 条

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[25] SYNTHESIS OF 20-EPI-ELDECALCITOL [20-EPI-1α,25-DIHYDROXY-2β-(3-HYDROXYPROPOXY)VITAMIN D3: 20-EPI-ED-71]
Yoshino, Madoka
Eto, Kohei
Takahashi, Keisuke
Ishihara, Jun
Hatakeyama, Susumi
Ono, Yoshiyuki
Saito, Hitoshi
Kubodera, Noboru
[J]. HETEROCYCLES, 2010, 81 (02) : 381 - 394

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