SYNTHESIS OF 1-DEOXYELDECALCITOL, A BIOLOGICALLY INTERESTING ANALOG OF 1α,25-DIHYDROXY-2β-(3-HYDROXYPROPOXY)VITAMIN D3 (ELDECALCITOL)

被引：3
作者：
Sasaki, Hirotaka [1 ]
Eto, Kohei [1 ]
Takahashi, Keisuke [1 ]
Ishihara, Jun [1 ]
Hatakeyama, Susumi [1 ]
Kubodera, Noboru [2 ]
机构：
[1] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 8528521, Japan
[2] Chugai Pharmaceut Co Ltd, Chuo Ku, Tokyo 1038324, Japan
来源：
HETEROCYCLES | 2011年 / 83卷 / 06期
关键词：
Calcitriol; Calcifediol; Eldecalcitol; 1-Deoxyeldecalcitol; Trost's Coupling Methodology; BONE-MINERAL LOSS; VITAMIN-D ANALOGS; OVARIECTOMIZED RATS; ED-71; DIASTEREOMER; CALCIUM; DERIVATIVES;
D O I：
10.3987/COM-11-12189
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A synthesis of biologically interesting 1-deoxyeldecalcitol, a dehydroxylated analog at the la-position of 1 alpha,25-dihydroxy-2 beta-(3-hydroxypropoxy)vitamin D-3 (eldecalcitol), using Trost's coupling methodology is described.
引用
收藏
页码：1385 / 1394
页数：10
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