Nucleic acid analog peptide (NAAP). Solid phase synthesis of a DNA analog peptide

被引：11

作者：

Fujii, M ^{[1
]}

Yamamoto, K ^{[1
]}

Hidaka, J ^{[1
]}

Ohtsu, T ^{[1
]}

机构：

[1] KINKI UNIV,FAC BIOL SCI & ENGN,DEPT GEN EDUC,WAKAYAMA 64964,JAPAN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 03期

关键词：

D O I：

10.1016/S0040-4039(96)02314-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Solid phase synthesis of a nucleic acid analog peptide (NAAP), as a substitute for antisense or triple-helix forming oligonucleotide, is described. The N-protected amino acid monomer was prepared starting from 3'-azido-3'-deoxythymidine (AZT) in 20% overall yield. Condensation of the amino acid monomer was performed using Boc-chemistry on MBHA resin to afford a decapeptide containing 10 thymine bases in 21% overall yield. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：417 / 420

页数：4

共 12 条

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