Diurnal variations in the human rest response to endotoxin

被引：80

作者：

Pollmacher, T ^{[1
]}

Mullington, J ^{[1
]}

Korth, C ^{[1
]}

Schreiber, W ^{[1
]}

Hermann, D ^{[1
]}

Orth, A ^{[1
]}

Galanos, C ^{[1
]}

Holsboer, F ^{[1
]}

机构：

[1] MAX PLANCK INST IMMUNBIOL,D-7800 FREIBURG,GERMANY

来源：

JOURNAL OF INFECTIOUS DISEASES | 1996年 / 174卷 / 05期

关键词：

D O I：

10.1093/infdis/174.5.1040

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To investigate diurnal variations in the host response to endotoxin, Salmonella abortus equi endotoxin (0.8 ng/kg) was given intravenously to healthy men in a placebo-controlled design at 0900 or 1900 h. The time courses of rectal temperature and the plasma levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), adrenocorticotropic hormone (ACTH), and cortisol were monitored for 11 h following the injections. The time of day did not affect the endotoxin-induced increase in plasma TNF-alpha or IL-6, However, subjects who received endotoxin in the evening, when endogenous glucocorticoid levels were low, showed about twice the increases in rectal temperature and plasma ACTH and cortisol levels as those who received endotoxin in the morning, when endogenous glucocorticoid levels were high, These results demonstrate diurnal variations in the human susceptibility to endotoxin that may be due to a suppression of the biologic effects of TNF-alpha and IL-S by endogenous glucocorticoids.

引用

页码：1040 / 1045

页数：6

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[21] CIRCADIAN DYNAMICS OF TUMOR-NECROSIS-FACTOR-ALPHA (CACHECTIN) LETHALITY [J].