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Electrospun Biomimetic Nanofibrous Scaffolds: A Promising Prospect for Bone Tissue Engineering and Regenerative Medicine
被引:93
作者:
Anjum, Shabnam
[1
]
Rahman, Farheen
[2
]
Pandey, Prashant
[3
]
Arya, Dilip Kumar
[3
]
Alam, Mahmood
[4
]
Rajinikanth, Paruvathanahalli Siddalingam
[3
]
Ao, Qiang
[1
,5
]
机构:
[1] China Med Univ, Sch Intelligent Med, Dept Tissue Engn, Shenyang 110122, Peoples R China
[2] Aligarh Muslim Univ, Dept Appl Chem, Zakir Husain Coll Engn & Technol, Aligarh 202002, Uttar Pradesh, India
[3] Babasaheb Bhimrao Ambedkar Univ, Dept Pharmaceut Sci, Vidya Vihar, Raebareli Rd, Lucknow 226025, Uttar Pradesh, India
[4] China Med Univ, Dept Clin Med, Shenyang 110122, Peoples R China
[5] Sichuan Univ, NMPA Key Lab Qual Res & Control Tissue Regenerat, Chengdu 610064, Peoples R China
基金:
国家重点研发计划;
关键词:
bone tissue regeneration;
nanofibrous scaffolds;
electrospinning;
nanofiber composite;
bone defects;
growth factor;
ENHANCED OSTEOGENIC DIFFERENTIATION;
GROWTH-FACTOR DELIVERY;
DRUG-DELIVERY;
COMPOSITE SCAFFOLDS;
STEM-CELLS;
CARBON NANOTUBES;
BIOMEDICAL APPLICATIONS;
BIOLOGICAL-PROPERTIES;
HYBRID NANOFIBERS;
FIBROUS SCAFFOLD;
D O I:
10.3390/ijms23169206
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Skeletal-related disorders such as arthritis, bone cancer, osteosarcoma, and osteoarthritis are among the most common reasons for mortality in humans at present. Nanostructured scaffolds have been discovered to be more efficient for bone regeneration than macro/micro-sized scaffolds because they sufficiently permit cell adhesion, proliferation, and chemical transformation. Nanofibrous scaffolds mimicking artificial extracellular matrices provide a natural environment for tissue regeneration owing to their large surface area, high porosity, and appreciable drug loading capacity. Here, we review recent progress and possible future prospective electrospun nanofibrous scaffolds for bone tissue engineering. Electrospun nanofibrous scaffolds have demonstrated promising potential in bone tissue regeneration using a variety of nanomaterials. This review focused on the crucial role of electrospun nanofibrous scaffolds in biological applications, including drug/growth factor delivery to bone tissue regeneration. Natural and synthetic polymeric nanofibrous scaffolds are extensively inspected to regenerate bone tissue. We focused mainly on the significant impact of nanofibrous composite scaffolds on cell adhesion and function, and different composites of organic/inorganic nanoparticles with nanofiber scaffolds. This analysis provides an overview of nanofibrous scaffold-based bone regeneration strategies; however, the same concepts can be applied to other organ and tissue regeneration tactics.
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