Electrospun Biomimetic Nanofibrous Scaffolds: A Promising Prospect for Bone Tissue Engineering and Regenerative Medicine

被引:93
作者
Anjum, Shabnam [1 ]
Rahman, Farheen [2 ]
Pandey, Prashant [3 ]
Arya, Dilip Kumar [3 ]
Alam, Mahmood [4 ]
Rajinikanth, Paruvathanahalli Siddalingam [3 ]
Ao, Qiang [1 ,5 ]
机构
[1] China Med Univ, Sch Intelligent Med, Dept Tissue Engn, Shenyang 110122, Peoples R China
[2] Aligarh Muslim Univ, Dept Appl Chem, Zakir Husain Coll Engn & Technol, Aligarh 202002, Uttar Pradesh, India
[3] Babasaheb Bhimrao Ambedkar Univ, Dept Pharmaceut Sci, Vidya Vihar, Raebareli Rd, Lucknow 226025, Uttar Pradesh, India
[4] China Med Univ, Dept Clin Med, Shenyang 110122, Peoples R China
[5] Sichuan Univ, NMPA Key Lab Qual Res & Control Tissue Regenerat, Chengdu 610064, Peoples R China
基金
国家重点研发计划;
关键词
bone tissue regeneration; nanofibrous scaffolds; electrospinning; nanofiber composite; bone defects; growth factor; ENHANCED OSTEOGENIC DIFFERENTIATION; GROWTH-FACTOR DELIVERY; DRUG-DELIVERY; COMPOSITE SCAFFOLDS; STEM-CELLS; CARBON NANOTUBES; BIOMEDICAL APPLICATIONS; BIOLOGICAL-PROPERTIES; HYBRID NANOFIBERS; FIBROUS SCAFFOLD;
D O I
10.3390/ijms23169206
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Skeletal-related disorders such as arthritis, bone cancer, osteosarcoma, and osteoarthritis are among the most common reasons for mortality in humans at present. Nanostructured scaffolds have been discovered to be more efficient for bone regeneration than macro/micro-sized scaffolds because they sufficiently permit cell adhesion, proliferation, and chemical transformation. Nanofibrous scaffolds mimicking artificial extracellular matrices provide a natural environment for tissue regeneration owing to their large surface area, high porosity, and appreciable drug loading capacity. Here, we review recent progress and possible future prospective electrospun nanofibrous scaffolds for bone tissue engineering. Electrospun nanofibrous scaffolds have demonstrated promising potential in bone tissue regeneration using a variety of nanomaterials. This review focused on the crucial role of electrospun nanofibrous scaffolds in biological applications, including drug/growth factor delivery to bone tissue regeneration. Natural and synthetic polymeric nanofibrous scaffolds are extensively inspected to regenerate bone tissue. We focused mainly on the significant impact of nanofibrous composite scaffolds on cell adhesion and function, and different composites of organic/inorganic nanoparticles with nanofiber scaffolds. This analysis provides an overview of nanofibrous scaffold-based bone regeneration strategies; however, the same concepts can be applied to other organ and tissue regeneration tactics.
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页数:33
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共 236 条
[1]   Nanosheets-incorporated bio-composites containing natural and synthetic polymers/ceramics for bone tissue engineering [J].
Adithya, S. Pranav ;
Sidharthan, D. Saleth ;
Abhinandan, R. ;
Balagangadharan, K. ;
Selvamurugan, N. .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 164 :1960-1972
[2]   Curcumin loaded polycaprolactone-/polyvinyl alcohol-silk fibroin based electrospun nanofibrous mat for rapid healing of diabetic wound: An in-vitro and in-vivo studies [J].
Agarwal, Yashi ;
Rajinikanth, P. S. ;
Ranjan, Shivendu ;
Tiwari, Upama ;
Balasubramnaiam, J. ;
Pandey, Prashant ;
Arya, Dilip Kumar ;
Anand, Sneha ;
Deepak, Payal .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 176 (176) :376-386
[3]   Metallic bone fixation implants: a novel design approach for reducing the stress shielding phenomenon [J].
Al-Tamimi, Abdulsalam A. ;
Fernandes, Paulo Rui Alves ;
Peach, Chris ;
Cooper, Glen ;
Diver, Carl ;
Bartolo, Paulo Jorge .
VIRTUAL AND PHYSICAL PROTOTYPING, 2017, 12 (02) :141-151
[4]   Extracellular matrix networks in bone remodeling [J].
Alford, Andrea I. ;
Kozloff, Kenneth M. ;
Hankenson, Kurt D. .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2015, 65 :20-31
[5]   Rationally design of electrospun polysaccharides polymeric nanofiber webs by various tools for biomedical applications: A review [J].
Alturki, Asma M. .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 184 :648-665
[6]   The synergistic effect of nano-hydroxyapatite and dexamethasone in the fibrous delivery system of gelatin and poly(L-lactide) on the osteogenesis of mesenchymal stem cells [J].
Amjadian, Sara ;
Seyedjafari, Ehsan ;
Zeynali, Bahman ;
Shabani, Iman .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 507 (1-2) :1-11
[7]   Bone tissue regeneration: biology, strategies and interface studies [J].
Ansari, Mojtaba .
PROGRESS IN BIOMATERIALS, 2019, 8 (04) :223-237
[8]   Biodegradable Polymers as Drug Delivery Systems for Bone Regeneration [J].
Aoki, Kaoru ;
Saito, Naoto .
PHARMACEUTICS, 2020, 12 (02)
[9]   Carbon nanotubes, science and technology part (I) structure, synthesis and characterisation [J].
Aqel, Ahmad ;
Abou El-Nour, Kholoud M. M. ;
Ammar, Reda A. A. ;
Al-Warthan, Abdulrahman .
ARABIAN JOURNAL OF CHEMISTRY, 2012, 5 (01) :1-23
[10]   Mechanical and biological properties of chitosan/carbon nanotube nanocomposite films [J].
Aryaei, Ashkan ;
Jayatissa, Ahalapitiya H. ;
Jayasuriya, Ambalangodage C. .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2014, 102 (08) :2704-2712