Sensitizing DNA Towards Low-Energy Electrons with 2-Fluoroadenine

被引：45
作者：
Rackwitz, Jenny [1 ]
Kopyra, Janina [2 ]
Dabkowska, Iwona [3 ]
Ebel, Kenny [1 ]
Rankovic, MiloS Lj. [4 ]
Milosavljevic, Aleksandar R. [4 ,5 ]
Bald, Ilko [1 ,6 ]
机构：
[1] Univ Potsdam, Inst Chem Phys Chem, Karl Liebknecht Str 24-25, D-14476 Potsdam, Germany
[2] Siedlce Univ, Fac Sci, 3 Maja 54, PL-08110 Siedlce, Poland
[3] Univ Gdansk, Dept Chem, PL-80952 Gdansk, Poland
[4] Univ Belgrade, Inst Phys Belgrade, Pregrevica 118, Belgrade 11080, Serbia
[5] SOLEIL, BP48, F-91192 Gif Sur Yvette, France
[6] BAM Fed Inst Mat Res & Testing, Dept Analyt Chem & Reference Mat 1, Richard Willstatter Str 11, D-12489 Berlin, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 35期
关键词：
ab initio calculations; dissociative electron attachment; DNA origami; DNA radiation damage; fludarabine; PLATINUM CHEMOTHERAPEUTIC DRUGS; STRAND BREAKS; CROSS-SECTIONS; NEGATIVE-IONS; PLASMID DNA; SINGLE; ATTACHMENT; RADIATION; NUCLEOBASES; DECOMPOSITION;
D O I：
10.1002/anie.201603464
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
2-Fluoroadenine ((2F)A) is a therapeutic agent, which is suggested for application in cancer radiotherapy. The molecular mechanism of DNA radiation damage can be ascribed to a significant extent to the action of low-energy (<20 eV) electrons (LEEs), which damage DNA by dissociative electron attachment. LEE induced reactions in (2F)A are characterized both isolated in the gas phase and in the condensed phase when it is incorporated into DNA. Information about negative ion resonances and anion-mediated fragmentation reactions is combined with an absolute quantification of DNA strand breaks in (2F)A-containing oligonucleotides upon irradiation with LEEs. The incorporation of (2F)A into DNA results in an enhanced strand breakage. The strand-break cross sections are clearly energy dependent, whereas the strand-break enhancements by (2F)A at 5.5, 10, and 15 eV are very similar. Thus, (2F)A can be considered an effective radiosensitizer operative at a wide range of electron energies.
引用
收藏
页码：10248 / 10252
页数：5
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