Total synthesis of proposed structure of polyporolide via acid catalyzed lactonization

被引：2

作者：

Kunde, Ramesh ^{[1
]}

Krishna, Palakodety Radha ^{[1
]}

机构：

[1] CSIR Indian Inst Chem Technol, Organ & Biomol Chem Div, Discovery Lab, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 25期

关键词：

Polyol gamma-butyrolactone; Polyporolide; Regioselective ring-opening reaction; D-Ribose; Intramolecular lactonization; STEREOSELECTIVE TOTAL-SYNTHESIS; ENANTIOSELECTIVE SYNTHESES; DERIVATIVES; ALCOHOLS; BEHAVIOR;

D O I：

10.1016/j.tetlet.2015.04.126

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report the total synthesis of proposed structure of polyporolide 1 via Barbier allylation, Sharpless epoxidation, Titanium(IV) promoted regioselective ring-opening reaction of epoxy homoallyl alcohol and acid catalyzed intramolecular lactonization as the key steps. Also a chiron approach was adopted for the same in greater overall yields. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：3928 / 3932

页数：5

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